Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function.
Inhalation of ultrafine and fine particulate matter disrupts systemic vascular function.
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DOI：
10.1249/00005768-200605001-01768
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发表时间：
2006-05
影响因子：
2.1
通讯作者：
K. Rundell;J. Hoffman;Renee Caviston;R. Bulbulian;Amanda M. Hollenbach
中科院分区：
文献类型：
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作者：
K. Rundell;J. Hoffman;Renee Caviston;R. Bulbulian;Amanda M. Hollenbach
本研究探讨了运动时吸入空气动力学直径为0.02-1 μ m的颗粒物（PM 1）对管道动脉和微血管功能的影响。吸入内部燃烧产生的PM与心血管死亡率和发病率相关。PM对血管内皮的直接作用是可能的，因为超细PM的大部分从肺泡转移到循环系统。16名校际运动员进行了30分钟的运动，同时吸入低或高的PM 1。在运动前和运动后，使用高分辨率超声检查进行血流介导的肱动脉扩张（FMD），同时使用近红外分光光度法（NIRS）测量前臂氧动力学。在高PM 1运动后发现基底肱动脉血管收缩（4.0%，4.66 +/- 0.609至4.47 +/- 0.625 mm直径; p = .0002），但在低PM 1运动后没有（-0.3%，4.66 +/- 0.626至4.68 +/- 0.613 mm直径）。高PM 1运动后FMD受损（运动前FMD为6.8 +/- 3.58%，运动后FMD为0.30 +/- 2.74%，p = 0.0001），但在低PM 1运动后FMD未受损（运动前FMD为6.6 +/- 4.04%，运动后FMD为4.89 +/- 4.42%）。对于高PM 1运动，观察到4分钟袖带缺血后通过复氧斜率至基线估计的前臂肌肉再灌注减少（55% vs. 3%，p = 0.0006）;对于低PM 1运动，未观察到差异。肱动脉FMD与肌肉复氧斜率至基线显著相关（r = 0.50，p = 0.005）。急性吸入城市环境中典型的高[PM 1]会损害全身导管动脉功能和微循环。袖带释放后观察到的复氧斜率至基线的降低与肌肉微血管中的血流减少一致。
This study investigated the effects of particulate matter (PM) with aerodynamic diameter 0.02-1 microm (noted as PM1) inhalation during exercise on conduit artery and microvascular function. Inhalation of internal combustion-derived PM is associated with cardiovascular mortality and morbidity. Direct action of PM on the vascular endothelium is likely, as a substantial fraction of ultrafine PM translocates from the alveoli to the circulatory system. Sixteen intercollegiate athletes performed 30 min of exercise while inhaling low or high PM1. Flow-mediated brachial artery dilation (FMD) using high-resolution ultrasonography with simultaneous measurements of forearm oxygen kinetics using near infrared spectrophotometry (NIRS) was done before and after exercise. Basal brachial artery vasoconstriction was found after high PM1 exercise (4.0%, 4.66 +/- 0.609 to 4.47 +/- 0.625 mm diameter; p = .0002), but not after low PM1 exercise (-0.3%, 4.66 +/- 0.626 to 4.68 +/- 0.613 mm diameter). FMD was impaired after high PM1 exercise (6.8 +/- 3.58% for preexercise FMD and 0.30 +/- 2.74% for postexercise FMD, p = .0001), but not after low PM1 exercise (6.6 +/- 4.04% for preexercise FMD and 4.89 +/- 4.42% for postexercise FMD). Reduction in forearm muscle reperfusion estimated by reoxygenation slope-to-baseline after 4 min cuff ischemia was observed for high PM1 exercise (55% vs. 3%, p = .0006); no difference was noted for low PM1 exercise. Brachial artery FMD was significantly correlated to muscle reoxygenation slope-to-baseline (r = .50, p = .005). Acute inhalation of high [PM1] typical of urban environments impairs both systemic conduit artery function and microcirculation. The observed decrease reoxygenation slope-to-baseline after cuff release is consistent with reduced blood flow in the muscle microvasculature.