Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine
Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine
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DOI：
10.1002/cbic.201200291
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发表时间：
2012-09-03
期刊：
影响因子：
3.2
通讯作者：
Casapullo, Agostino
中科院分区：
文献类型：
--
作者：
Cassiano, Chiara;Monti, Maria Chiara;Casapullo, Agostino
海洋生物活性化合物因其对人类疾病的多种药理作用而成为潜在的药物先导。它们的细胞靶点的鉴定对于合理地应用它们在药物化学中是至关重要的。因此，我们分析了细胞相互作用组的suvanine，硫酸三环萜类化合物的海洋起源赋予一个有趣的抗炎活性，通过应用化学蛋白质组学方法。热休克蛋白60是一种参与炎症反应的伴侣蛋白，是苏瓦宁的主要细胞靶点，也能够干扰蛋白伴侣蛋白的活性，为其抗炎特性提供了证据。
Marine bioactive compounds are potential drug leads because of their diverse pharmacological effects against human diseases. The identification of their cellular targets is crucial for a rational approach to their application in medicinal chemistry. Thus, we have analyzed the cell interactome of suvanine, a sulfated tricyclic terpenoid of marine origin endowed with an interesting anti-inflammatory activity, by application of a chemical proteomic approach. Heat Shock Protein 60, a chaperone involved in the inflammatory response, is the main cellular target of suvanine, which is also able to interfere with protein chaperone activity, giving evidence for its anti-inflammatory properties.