Characteristics of Esophageal Cancer Cases in Tanzania.
Characteristics of Esophageal Cancer Cases in Tanzania.
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DOI：
10.1200/jgo.2016.006619
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发表时间：
2018-09
影响因子：
--
通讯作者：
Van Loon K
中科院分区：
文献类型：
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作者：
Mmbaga EJ;Deardorff KV;Mushi B;Mgisha W;Merritt M;Hiatt RA;Mwaiselage J;Zhang L;Van Loon K
据报道，东非食管癌（EC）的标准化发病率与世界范围内每10万人9例的发病率相比不成比例地高。本研究旨在描述坦桑尼亚达累斯萨拉姆Muhimbili国家医院和海洋路癌症研究所的EC病例。从2011年至2013年期间在一个或两个机构接受EC诊断治疗的患者图表中提取人口统计学，临床和治疗变量。分类数据总结为频率计数和百分比。连续数据以中位数和范围表示。为了比较男性和女性，应用Pearson χ2和双样本t检验。确定了738例独特的EC病例，其中68%为男性，中位年龄为60岁（范围为19至95岁）。值得注意的是，93例病例（13%）在诊断时≤ 40岁。鳞状细胞癌是主要的组织学类型，占有组织病理学记录病例的90%。然而，34%的诊断为EC的病例未得到病理证实。在4%的病例中，分期记录为局部区域性，20%的病例为局部晚期，14%的病例为转移性，63%的病例为未知。在Ocean Road癌症研究所接受治疗的430名患者中，76%接受了放射治疗，44%接受了化疗，3%接受了癌症相关的外科手术，10%的病例没有接受癌症导向治疗。所有患者的中位总生存期为6.9个月（95% CI，5.0 - 12.8），不考虑就诊时的分期。在2011年至2013年期间，EC病例在这两个机构都是一个巨大的临床负担。
Age-standardized incidence rates for esophageal cancer (EC) in East Africa have been reported as disproportionately high compared with the worldwide incidence of nine per 100,000 population. This study aimed to characterize EC cases seen at Muhimbili National Hospital and Ocean Road Cancer Institute in Dar es Salaam, Tanzania. Demographic, clinical, and treatment variables were abstracted from charts of patients who received care for a diagnosis of EC at one or both institutions between 2011 and 2013. Categorical data were summarized as frequency counts and percentages. Continuous data were presented as medians and ranges. To compare men and women, Pearson’s χ2 and two-sample t tests were applied. Seven hundred thirty-eight unique cases of EC were identified, of whom 68% were men and the median age was 60 years (range, 19 to 95 years). Notably, 93 cases (13%) were ≤ 40 years old at diagnosis. Squamous cell carcinoma was the dominant histology, comprising 90% of cases with documented histopathology. However, 34% of cases with a diagnosis of EC were not pathologically confirmed. The stage was documented as locoregional in 4% of cases, locally advanced in 20% of cases, metastatic in 14% of cases, and unknown in 63% of cases. Of 430 patients who received treatment at Ocean Road Cancer Institute, 76% were treated with radiation, 44% were treated with chemotherapy, 3% underwent a cancer-related surgical procedure, and 10% of cases received no cancer-directed therapy. The median overall survival for all patients was 6.9 months (95% CI, 5.0 to 12.8), regardless of stage at presentation. Between 2011 and 2013, cases of EC represented a large clinical burden at both institutions.