Indomethacin release behaviors from pH and thermoresponsive poly(vinyl alcohol) and poly(acrylic acid) IPN hydrogels for site‐specific drug delivery
Indomethacin release behaviors from pH and thermoresponsive poly(vinyl alcohol) and poly(acrylic acid) IPN hydrogels for site‐specific drug delivery
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DOI：
10.1002/(sici)1097-4628(19970725)65:4
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发表时间：
1997-07
影响因子：
3
通讯作者：
Heungsoo Shin;So Yeon Kim;Y. Lee
中科院分区：
文献类型：
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作者：
Heungsoo Shin;So Yeon Kim;Y. Lee
采用聚丙烯酸（PAAc）和聚乙烯醇（PVA）构筑互穿聚合物网络（IPN）水凝胶，研究了温度和ph响应的给药系统。结合到这些水凝胶中的吲哚美辛的释放随pH值和温度的变化呈脉动型。吲哚美辛通过溶胀和溶胀机制从聚合物基质中扩散。温度越高，释放量越大，这是由于氢键离解引起的溶胀。药物释放的剧烈变化是通过缓冲溶液的pH变化来实现的，这是由于IPN水凝胶中离子基团状态的变化。用差示扫描量热法（DSC）计算了游离水的含量，证明了游离水是引起溶胀的主要因素。这些结果表明，IPN水凝胶的溶胀程度可以作为pH和/或温度的函数来控制药物的释放。©1997 John Wiley & Sons, Inc[J] .华北农学报，25 (5):387 - 398
A temperature- and pH-responsive drug delivery system was studied by using interpenetrating polymer network (IPN) hydrogels constructed with poly(acrylic acid) (PAAc) and poly(vinyl alcohol) (PVA). The release of indomethacin incorporated into these hydrogels showed pulsatile patterns in response to both pH and temperature. Indomethacin diffused from the polymer matrices through the swelling and deswelling mechanism. The release amount increased at higher temperature because of the swelling caused by the dissociation of hydrogen bonding. The drastic change of drug release was achieved by alternating pH of the buffer solution and was attributed to the change of states of ionic groups within IPN hydrogels. The free water contents were calculated by using differential scanning calorimetry (DSC), and were proved to be the main factor in the swelling. These results demonstrated that the drug release could be controlled by the swelling/deswelling degree of IPN hydrogels as functions of pH and/or temperature. © 1997 John Wiley & Sons, Inc. J Appl Polm Sci 65: 685–693