Patterns of aspirin use in middle-aged adults: The atherosclerosis risk in communities (ARIC) study
Patterns of aspirin use in middle-aged adults: The atherosclerosis risk in communities (ARIC) study
复制标题
DOI：
10.1016/s0002-8703(96)90173-8
复制
发表时间：
1996-05-01
影响因子：
4.8
通讯作者：
Heiss, G
中科院分区：
文献类型：
--
作者：
Shahar, E;Folsom, AR;Heiss, G
为了确定中年男性和女性阿司匹林使用的相关性和近期趋势，我们分析了来自美国四个社区的基于人群的样本数据。阿司匹林的使用（在研究检查前的2周内）在白人中比在黑人中更普遍（30%比11%，p < 0.001），在白人中男性比女性更普遍（31%比28%，p < 0.002），但在黑人中不是（男女均为10%）。在所有四个种族和性别组中，估计的冠心病（CHD）风险与阿司匹林使用的年龄调整患病率之间存在分级正相关。例如，报告诊断为高胆固醇血症和高血压并且曾经吸烟的无冠心病白人男性中有33%报告使用阿司匹林，而无危险因素的对照组中有25%报告使用阿司匹林（p < 0.001）。在有症状的冠心病或冠心病高危人群中，随着阿司匹林一级预防试验结果的公布，1987年至1989年间阿司匹林的使用量增加了4个百分点。然而，近50%报告有心肌梗死史的参与者显然没有定期服用阿司匹林。
To determine correlates of and recent trends in aspirin use in middle-age men and women, we analyzed data from population-based samples selected in four U.S. communities. Aspirin use (during a 2-week period preceding the study examination) was more prevalent in whites than in blacks (30% vs 11%; p < 0.001) and in men than in women among whites (31% vs 28%; p < 0.002) but not blacks (10% in both sexes). In all four race and sex groups, there was a graded positive relation between estimated coronary heart disease (CHD) risk and age-adjusted prevalence of aspirin use. For example, 33% of CHD-free white men who reported diagnoses of hypercholesterolemia and hypertension and had ever smoked reported aspirin use as compared with 25% of their risk factor-free counterparts (p < 0.001). Among men with symptomatic CHD or at high risk for CHD, aspirin use increased by four percentage points between 1987 and 1989 in conjunction with the publication of results from the aspirin primary prevention trials. However, nearly 50% of participants reporting a history of myocardial infarction apparently did not take aspirin regularly.