The role of photodynamic therapy in the esophagus.
The role of photodynamic therapy in the esophagus.
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DOI：
10.1016/j.giec.2009.07.008
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Wolfsen, Herbert C
中科院分区：
文献类型：
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作者：
Gross, Seth A;Wolfsen, Herbert C
光动力疗法（PDT）是一种利用激光激活光敏剂药物进行粘膜消融的药物和设备疗法。 Porfimer钠PDT已广泛用于Barrett食管和高度不典型增生的消融，并已被证明具有长期疗效和持久性。以及早期食管腺癌。然而，继续使用会受到相关狭窄风险和长时间光敏性（4-6 周）的阻碍。使用其他形式的 PDT（例如氨基乙酰丙酸 PDT）的有前途的单中心欧洲研究尚未在其他地方复制，限制了其他形式的 PDT 的广泛使用。 PDT 在食管疾病中的未来应用取决于改进的剂量测定和患者选择的发展，以优化治疗结果，同时最大限度地减少不良事件和并发症。
Photodynamic therapy (PDT) is a drug and device therapy using photosensitizer drugs activated by laser light for mucosal ablation. Porfimer sodium PDT has been used extensively with proven long-term efficacy and durability for the ablation of Barrett esophagus and high-grade dysplasia. and early esophageal adenocarcinoma. However, continued use is hampered by an associated stricture risk and prolonged photosensitivity (4-6 weeks). Promising single-center European studies using other forms of PDT, such as aminolevulinic acid PDT, have not been replicated elsewhere, limiting the widespread use of other forms of PDT. Future use of PDT in esophageal disease depends on the development of improved dosimetry and patient selection to optimize treatment outcomes, while minimizing adverse events and complications.