A novel CT-responsive hydrogel for the construction of an organ simulation phantom for the repeatability and stability study of radiomic features
A novel CT-responsive hydrogel for the construction of an organ simulation phantom for the repeatability and stability study of radiomic features
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一种新型的CT响应水凝胶用于器官模拟体模的构建，用于放射组学特征的可重复性和稳定性研究
DOI：
10.1039/d3tb01706k
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发表时间：
2023-11-07
影响因子：
7
通讯作者：
Wang，Xu
中科院分区：
文献类型：
--
作者：
Gu，Xiaokai;Shu，Zhenyu;Wang，Xu
放射组学特征在肿瘤分级和检测医学成像分析中的癌前病变方面已证明是可靠的结果。然而，这些特征的可重复性和稳定性受到了批评。在这项研究中，我们的目的是通过引入一种新的CT响应水凝胶材料，以提高放射性特征的可重复性和稳定性。新开发的CT响应水凝胶，矿化的原位金属离子，表现出卓越的可重复性，稳定性和均匀性。此外，通过调节金属离子的浓度，它实现了与CT扫描上的人体器官相当的显著CT相似性。为了创建体模，将水凝胶模制成通用模型，显示范围从53 HU到58 HU的可控CT值，类似于人类肝脏组织。随后，从CT响应性水凝胶器官模拟体模中提取1218个放射组学特征。令人印象深刻的是，85-97.2%的提取的特征表现出良好的重复性和稳定性的变异系数分析。这一发现强调了CT响应性水凝胶在一致提取相同特征方面的潜力，提供了一种解决放射组学特征可重复性问题的新方法。
Radiomic features have demonstrated reliable outcomes in tumor grading and detecting precancerous lesions in medical imaging analysis. However, the repeatability and stability of these features have faced criticism. In this study, we aim to enhance the repeatability and stability of radiomic features by introducing a novel CT-responsive hydrogel material. The newly developed CT-responsive hydrogel, mineralized by in situ metal ions, exhibits exceptional repeatability, stability, and uniformity. Moreover, by adjusting the concentration of metal ions, it achieves remarkable CT similarity comparable to that of human organs on CT scans. To create a phantom, the hydrogel was molded into a universal model, displaying controllable CT values ranging from 53 HU to 58 HU, akin to human liver tissue. Subsequently, 1218 radiomic features were extracted from the CT-responsive hydrogel organ simulation phantom. Impressively, 85–97.2% of the extracted features exhibited good repeatability and stability during coefficient of variability analysis. This finding emphasizes the potential of CT-responsive hydrogel in consistently extracting the same features, providing a novel approach to address the issue of repeatability in radiomic features.