Diurnal and Seasonal Occurrence of Febrile Seizures
Diurnal and Seasonal Occurrence of Febrile Seizures
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DOI：
10.1016/j.pediatrneurol.2015.01.001
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发表时间：
2015-04-01
影响因子：
3.8
通讯作者：
Rantala, Heikki
中科院分区：
文献类型：
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作者：
Mikkonen, Kirsi;Uhari, Matti;Rantala, Heikki
背景：热性惊厥是儿童最常见的惊厥，但其发病机制尚不清楚。一些研究表明，褪黑素的光依赖性分泌与热性惊厥的发生有关。高热惊厥的昼夜和季节性发生可以阐明日光在高热惊厥中所起的作用。方法：在芬兰，夏天白天长而明亮，冬天白天短而暗。在一项基于人群的研究中，我们评估了461名儿童首次发热性惊厥的昼夜和季节性发生情况，并根据发热性发作的流行病学对其进行了调整。结果：首次发热性惊厥最多发生在傍晚，高峰出现在6~10点(31%)，最少出现在夜间，出现在凌晨2~6点(8%)(P<；0.001)。这种昼夜模式根据日照时数的变化在不同的季节重复出现。发热发作全年无规律地发生，冬季最常见，与发热发作同时发生，夏季最少；这种季节性变化的发生。然而，根据发烧事件的数量进行调整后，发烧发作消失了。结论：我们发现热性惊厥的发生有明显的昼夜和季节变化，即使它们不跟随日照的量。我们的发现不支持这样的假设，即白天的昼夜和季节变化解释了热性癫痫的发生。此外，发热事件与热性惊厥的发生密切相关。
BACKGROUND: Febrile seizures are the most common seizures in children, but their pathogenesis remains unknown. Some studies have suggested an association between the light-dependent secretion of melatonin and the occurrence of febrile seizures. The diurnal and seasonal occurrence of febrile seizures could clarify the role daylight plays in febrile seizures. METHODS: In Finland, summer days are long and bright and winter days are short and dark. We evaluated the diurnal and seasonal occurrence of the first febrile seizures in 461 children and adjusted them according to the epidemiology of the febrile episodes in a population-based study of 1522 children. RESULTS: The first febrile seizure most often occurred in the evening, peaking between 6 and 10 PM (31%), and least often at night, in the early morning hours between 2 and 6 AM (8%) (P < 0.001). This diurnal pattern repeated itself in different seasons according to variance in daylight duration. Febrile seizures occurred irregularly throughout the year, most frequently in winter, concurrently with the febrile episodes, and least frequently in summer; this seasonal variation in the occurrence of. febrile seizures disappeared however when adjusted for the number of febrile events. CONCLUSIONS: We found clear diurnal and seasonal variations in the occurrence of febrile seizures, even though they did not follow the amount of daylight. Our findings do not support the hypothesis that the diurnal and seasonal variation of daylight explains the occurrence of febrile seizures. Moreover, febrile events associated strongly with the occurrence of febrile seizures.