Effect of Maternal Age on the Risk of Stillbirth: A Population-Based Cohort Study on 37 Million Births in the United States
Effect of Maternal Age on the Risk of Stillbirth: A Population-Based Cohort Study on 37 Million Births in the United States
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DOI：
10.1055/s-0031-1276739
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发表时间：
2011-09-01
影响因子：
2
通讯作者：
Abenhaim, Haim A.
中科院分区：
文献类型：
--
作者：
Balayla, Jacques;Azoulay, Laurent;Abenhaim, Haim A.
本研究的目的是评估母亲年龄对死产风险的影响。我们使用疾病控制和预防中心的“婴儿死亡相关”和“胎儿死亡”数据文件进行了一项基于人群的队列研究。我们排除了所有胎龄在24周以下的新生儿和报告有先天性畸形的新生儿。我们用逻辑回归分析估计了母亲年龄对死产风险的调整效应。有37，504，230例分娩符合研究标准，其中130，353例（3.5/1，000）为死产。死产率在这10年中保持不变。与年龄在25 - 30岁之间的妇女相比，母亲年龄的降低与以下死产风险相关：比值比（OR）0.95（95%置信区间[CI] 0.93 - 0.97）; OR 0.97（95% CI 0.94 - 0.99）（15 - 20岁）; OR 1.32（95% CI 1.18 - 1.47）（45岁）。虽然总体风险较低，但在生育年龄范围的极端妇女中，死产的风险大大增加。在这些妇女中，产前监测可能是合理的。
The objective of our study was to evaluate the incidence and effect of maternal age on the risk of stillbirth. We conducted a population-based cohort study using the Centers for Disease Control and Prevention's "Linked Birth-Infant Death" and "Fetal Death" data files. We excluded all births of gestational age under 24 weeks and those with reported congenital malformations. We estimated the adjusted effect of maternal age on the risk of stillbirth using logistic regression analysis. There were 37,504,230 births that met study criteria, of which 130,353 (3.5/1,000) were stillbirths. Rates of stillbirth remained constant throughout the 10 years. As compared with women between the ages of 25 and 30, decreasing maternal age was associated with the following risk of stillbirth: odds ratio (OR) 0.95 (95% confidence interval [CI] 0.93 to 0.97) for ages 20 to 25; OR 0.97 (95% CI 0.94 to 0.99) for ages 15 to 20; and OR 1.32 (95% CI 1.18 to 1.47) for ages 45. Although the overall risk is low, the risk of stillbirth increases considerably in women at the extremes of the reproductive age spectrum. Antenatal surveillance may be justified in these women.