Toward a Visible Light Mediated Photocyclization: Cu-Based Sensitizers for the Synthesis of [5]Helicene
Toward a Visible Light Mediated Photocyclization: Cu-Based Sensitizers for the Synthesis of [5]Helicene
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DOI：
10.1021/ol300983b
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发表时间：
2012-06-15
期刊：
影响因子：
5.2
通讯作者：
Collins, Shawn K.
中科院分区：
文献类型：
--
作者：
Hernandez-Perez, Augusto C.;Vlassova, Anna;Collins, Shawn K.
已经开发了使用铜基敏化剂7的[5]螺烯的光化学合成，其避免了与传统UV光介导方法相关的缺点。可见光介导的合成使用普通玻璃器皿和简单的家用灯泡，而没有竞争形成[2 + 2]环加合物，区域异构体或过氧化产物苯并[ghi]二萘嵌苯3。初步结果表明，反应时间可以显着减少，通过使用连续流策略。
A photochemical synthesis of [5]helicene employing a copper-based sensitizer 7 has been developed that avoids the disadvantages associated with the traditional UV light mediated method. The visible light mediated synthesis uses common glassware and a simple household light bulb without the competing formation of [2 + 2] cycloadducts, regioisomers, or the overoxidation product benzo[ghi]perylene 3. Preliminary results show that the reaction time can be significantly reduced through the use of a continuous flow strategy.