Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass.
Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass.
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DOI：
10.2174/187152210793663748
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Lee SJ
中科院分区：
文献类型：
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作者：
Lee SJ
肌生长抑制素（Myostatin，MSTs）是一种转化生长因子-β家族成员，在调节骨骼肌质量中起着关键作用.在多个物种中的遗传研究表明，由于纤维数量增加和纤维尺寸增加的组合，Mexo基因的突变导致肌肉质量的急剧和广泛增加。当给予成年小鼠时，MMP 3抑制剂也显示出引起肌肉生长的显著增加。因此，人们进行了广泛的努力来了解MMP 3调控和活性的潜在机制，目的是开发最有效的策略来靶向该信号通路用于临床应用。在这里，我回顾了有关通过结合蛋白在细胞外调节MSTN的知识现状，并讨论了这些发现对MSTN在调节组织稳态中发挥的基本生理作用以及治疗药物开发的影响。对抗肌肉损失。
Myostatin (MSTN) is a transforming growth factor-ß family member that plays a critical role in regulating skeletal muscle mass. Genetic studies in multiple species have demonstrated that mutations in the Mstn gene lead to dramatic and widespread increases in muscle mass as a result of a combination of increased fiber numbers and increased fiber sizes. MSTN inhibitors have also been shown to cause significant increases in muscle growth when administered to adult mice. As a result, there has been an extensive effort to understand the mechanisms underlying MSTN regulation and activity with the goal of developing the most effective strategies for targeting this signaling pathway for clinical applications. Here, I review the current state of knowledge regarding the regulation of MSTN extracellularly by binding proteins and discuss the implications of these findings both with respect to the fundamental physiological role that MSTN plays in regulating tissue homeostasis and with respect to the development of therapeutic agents to combat muscle loss.