Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.
Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck.
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DOI：
10.1158/1055-9965.epi-11-0890
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Wei Q
中科院分区：
文献类型：
--
作者：
Liu Z;Ma H;Wei S;Li G;Sturgis EM;Wei Q
最近的研究报道了相对端粒长度(RTL)和TERT变异与几种癌症风险的关系，这在头颈部鳞状细胞癌(SCCHN)中还没有得到全面的研究。我们检测了888例SCCHN患者和885例非西班牙裔白人的外周血淋巴细胞中的RTL，并检测了TERT基因的6个选择性功能单核苷酸多态(SNPs)。总体而言，我们没有观察到RTL和SCCHN风险之间的显著关联(调整后的OR为0.97；95%CI，0.80-1.17，P趋势=0.618)，也没有观察到6个TERT SNP与SCCHN风险之间的显著关联。我们也没有发现RTL和TERT SNPs之间的关联。我们的结果提示，RTL和TERT功能多态性在SCCHN的病因中可能不起主要作用。我们需要大量的前瞻性研究来验证我们的发现。虽然我们的结果表明RTL、TERT功能多态和SCCHN风险之间没有关联，但这项研究可能有助于未来的荟萃分析。
Recent studies reported associations of the relative telomere length (RTL) and TERT variants with risk of several cancers, which has not been comprehensively investigated in squamous cell carcinoma of the head and neck (SCCHN). We detected RTL in peripheral blood lymphocytes and genotyped six selected functional single nucleotide polymorphisms (SNPs) of the TERT gene in 888 SCCHN cases and 885 cancer-free controls of non-Hispanic whites. Overall, we did not observe significant associations between RTL and SCCHN risk (adjusted OR, 0.97; 95% CI, 0.80–1.17 for below versus above the median; Ptrend = 0.618) nor between the six TERT SNPs and SCCHN risk. We also found no associations between RTL and TERT SNPs. Our results suggest that RTL and TERT functional polymorphisms may not play a major role in the etiology of SCCHN. Large prospective studies are needed to validate our findings. Although our results suggest no association among RTL, TERT functional polymorphisms, and SCCHN risk, this study may contribute to future meta-analysis.