The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition.
The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition.
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DOI：
10.18632/oncotarget.13833
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发表时间：
2017-01-17
期刊：
影响因子：
--
通讯作者：
Derenzini M
中科院分区：
文献类型：
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作者：
Onofrillo C;Galbiati A;Montanaro L;Derenzini M
核糖体前复合体RPL5/RPL11/5S rRNA （5S RNP）被认为是核糖体生物发生抑制过程中控制p53稳定的核心MDM2抑制复合体。尽管它的作用是明确的，但5S RNP组装的动态仍然需要进一步的表征。在目前的工作中，我们报道MDM2的抑制依赖于预先存在的5S rRNA群体。
Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.