A Nation‐wide Cross‐sectional Study of Glycosylated Haemoglobin in Danish Children with Type 1 diabetes
A Nation‐wide Cross‐sectional Study of Glycosylated Haemoglobin in Danish Children with Type 1 diabetes
复制标题
丹麦 1 型糖尿病儿童糖基化血红蛋白的全国横断面研究
DOI：
10.1111/j.1464-5491.1988.tb01127.x
复制
发表时间：
1988
影响因子：
3.5
通讯作者：
K. Petersen
中科院分区：
文献类型：
--
作者：
H. Mortensen;S. Hartling;K. Petersen
在丹麦进行了全国范围的HbA 1c筛查。21个治疗1型糖尿病儿童的儿科部门参与了研究。在为期4个月的研究中，纳入了884名儿童，占这些中心所有随访儿童的93%，约占丹麦所有1型糖尿病儿童和青少年的70-80%。其中351例为≤ 12岁儿童，533例为12 - 18岁青少年。≤ 12岁儿童的HbA 1c浓度为8.9 ± 1.5（± SD）%，胰岛素剂量为0.71 ± 0.3 U kg−1 24-h−1。对于青少年，HbA 1c显著升高9.7 ± 2.0%（p < 0.001），胰岛素剂量显著增加0.85 ± 0.3 U kg−1 24-h−1（p < 0.001）。HbA 1c '的正常范围为总血红蛋白的4.0- 6.5%（平均5.3%）。≤ 12岁的男孩和女孩的HbA 1c '相似，但女孩接受的胰岛素多13%（p < 0.001）。在青少年组中，女孩的HbA 1c比男孩高4%（9.9 ± 2.0 vs 9.5 ± 2.0%p < 0.025），接受的胰岛素多11%（p < 0.001），体重指数高6%（p < 0.001）。胰岛素剂量与HbA 1c水平之间存在弱相关性（r = 0.29，p < 0.001）。儿童和青少年每天注射4次或更多次胰岛素，比常规治疗组接受的胰岛素明显更多（p < 0.001），体重指数也明显更高（p < 0.001）。这些变化在女孩中最为明显，尽管接受了15%以上的胰岛素，但HbA 1c水平显著较高（9.9 ± 1.8 vs 9.3 ± 1.9%，p < 0.005），体重指数高12%（p < 0.001）。此外，身高的标准差评分随着疾病持续时间的延长而降低，在HbA 1c值最高的儿童中更是如此。我们的数据证实，目前在丹麦儿童糖尿病的治疗产生不令人满意的结果。
A nation‐wide screening for HbA1c was carried out in Denmark. Twenty‐one paediatric departments treating children with Type 1 diabetes participated. During a period of 4 months 884 children were included, 93% of all those followed at these centres, representing approximately 70–80% of all children and adolescents with Type 1 diabetes in Denmark. Among the children 351 were ≤ 12 years and 533 were adolescents between 12 and 18 years. Children ≤ 12 years had a HbA1c concentration of 8.9 ± 1.5 (± SD)% and an insulin dose of 0.71 ± 0.3 U kg−1 24‐h−1. For adolescents HbA1c was significantly higher 9.7 ± 2.0% (p < 0.001) and insulin dose significantly increased 0.85 ± 0.3 U kg−1 24‐h−1 (p < 0.001). Normal range for HbA1c' is 4.0–6.5 (mean 5.3)% of total haemoglobin. Boys and girls ≤ 12 years had similar HbA1c' but girls received 13% more insulin (p < 0.001). In the group of adolescents, girls had a HbA1c 4% higher than boys (9.9 ± 2.0 vs 9.5 ± 2.0%p < 0.025), received 11% more insulin (p < 0.001), and had 6% higher body mass index (p < 0.001). A weak correlation was found between insulin dose and the HbA1c level (r = 0.29, p < 0.001). Children and adolescents on four or more injections daily received significantly more insulin (p < 0.001) than those on conventional treatment and had a significantly higher body mass index (p < 0.001). These changes were most pronounced for girls who, despite receiving 15% more insulin, had a significantly higher HbA1c level (9.9 ± 1.8 vs 9.3 ± 1.9%, p < 0.005) and 12% higher body mass index (p < 0.001). Furthermore standard deviation score for height decreased with longer duration of the disease and more so in children with the highest HbA1c values. Our data confirm that current treatment of childhood diabetes in Denmark produces unsatisfactory results.
影响因子：
158.5
作者：
AMIEL, SA;SHERWIN, RS;TAMBORLANE, WV
通讯作者：
TAMBORLANE, WV
最近患糖尿病的儿童依从性的心理预测因素。
DOI：
10.1016/s0022-3476(87)80030-6
发表时间：
1987
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Jacobson,AM;Hauser,ST;Wolfsdorf,JI;Houlihan,J;Milley,JE;Herskowitz,RD;Wertlieb,D;Watt,E
通讯作者：
Watt,E