Dietary fiber and risk of coronary heart disease - A pooled analysis of cohort studies
Dietary fiber and risk of coronary heart disease - A pooled analysis of cohort studies
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DOI：
10.1001/archinte.164.4.370
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发表时间：
2004-02-23
影响因子：
--
通讯作者：
Ascherio, A
中科院分区：
文献类型：
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作者：
Pereira, MA;O'Reilly, E;Ascherio, A
背景：很少有关于膳食纤维摄入量和冠心病风险的流行病学研究比较纤维类型（谷物、水果和蔬菜）或包括性别特异性结果。本研究的目的是对膳食纤维及其亚型与冠心病风险进行汇总分析。方法：我们分析了来自美国和欧洲的 10 项前瞻性队列研究的原始数据，以估计膳食纤维摄入量与冠心病风险之间的关联。结果：经过 6 至 10 年的随访，共有 5249 例冠心病病例，2011 年冠心病死亡人数为 91058 人。 男性和 245 186 名女性。在对人口统计、体重指数和生活方式因素进行调整后，能量调整和测量误差校正后的总膳食纤维每增加 10 克/天，所有冠状动脉事件的风险就会降低 14%（相对风险 [RR]，0.86；95% 置信区间 [CI]，0.78-0.96），降低 27%（RR，0.73；95% Cl， 0.61-0.87) 冠心病死亡风险降低。对于谷物、水果和蔬菜纤维摄入量（未校正误差），对于所有冠状动脉事件，与 10 克/天增量相对应的 RR 分别为 0.90（95% Cl，0.77-1.07）、0.84（95% Cl，0.70-0.99）和 1.00（95% Cl，0.88-1.13），以及 0.75（95% Cl）。氯,0.63-0.91), 死亡分别为 0.70 (95% CI, 0.55-0.89) 和 1.00 (95% CI, 0.82-1.23)。男性和女性的结果相似。结论：谷物和水果中膳食纤维的摄入量与冠心病风险呈负相关。
Background: Few epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its sub-types and risk of coronary heart disease.Methods: We analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease.Results: Over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245 186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% Cl, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% Cl, 0.77-1.07), 0.84 (95% Cl, 0.70-0.99), and 1.00 (95% Cl, 0.88-1.13), respectively, for all coronary events and 0.75 (95% Cl, 0.63-0.91), 0.70 (95% Cl, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women. Conclusion: Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease.