GPRC6a is not required for the effects of a high-protein diet on body weight in mice.
GPRC6a is not required for the effects of a high-protein diet on body weight in mice.
复制标题
DOI：
10.1002/oby.21083
复制
发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Murphy KG
中科院分区：
文献类型：
--
作者：
Kinsey-Jones JS;Alamshah A;McGavigan AK;Spreckley E;Banks K;Cereceda Monteoliva N;Norton M;Bewick GA;Murphy KG
G 蛋白偶联受体家族 C 组 6 成员 A (GPRC6A) 被蛋白氨基酸激活，并且可以感知胃肠道和大脑中的氨基酸。该研究调查了 GPRC6A 是否是低蛋白和高蛋白饮食对小鼠体重和食物摄入量影响所必需的。在 GPRC6a 敲除 (GPRC6a-KO) 和野生型 (WT) 小鼠中研究了 GPRC6A 在介导低蛋白饮食对体重影响中的作用，这些小鼠喂食对照饮食（18% 蛋白质）或低蛋白饮食（6% 蛋白质）9 天。在喂食对照饮食（18％蛋白质）或高蛋白饮食（50％蛋白质）5周的GPRC6a-KO和WT小鼠中研究了GPRC6A在介导高蛋白饮食对体重影响中的作用。与 WT 和 GPRC6a-KO 小鼠的对照饮食相比，高蛋白饮食减少了体重增加和食物摄入量。低蛋白饮食降低了 GPRC6a-KO 小鼠的体重增加。 GPRC6A对于低蛋白或高蛋白饮食对体重的影响不是必需的，并且可能在蛋白质引起的饱腹感中不起作用。
The G-protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low- and high-protein diets on body weight and food intake in mice. The role of GPRC6A in mediating the effects of a low-protein diet on body weight was investigated in GPRC6a knockout (GPRC6a-KO) and wild-type (WT) mice fed a control diet (18% protein) or a low-protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high-protein diet on body weight was investigated in GPRC6a-KO and WT mice fed a control diet (18% protein) or a high-protein diet (50% protein) for 5 weeks. A high-protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a-KO mice. A low-protein diet decreased body weight gain in GPRC6a-KO mice. GPRC6A was not necessary for the effects of a low- or high-protein diet on body weight and likely does not play a role in protein-induced satiety.