Amphetamine-induced recovery of visual cliff performance after bilateral visual cortex ablation in cats: measurements of depth perception thresholds.
Amphetamine-induced recovery of visual cliff performance after bilateral visual cortex ablation in cats: measurements of depth perception thresholds.
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DOI：
10.1037//0735-7044.103.3.574
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发表时间：
1989-06
影响因子：
1.9
通讯作者：
D. Hovda;R. Sutton;Dennis M. Feeney
中科院分区：
文献类型：
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作者：
D. Hovda;R. Sutton;Dennis M. Feeney
在双侧视皮层消融后，猫表现出视觉悬崖上测量的深度知觉丧失，其在d-苯丙胺给药后恢复。在这项研究中，3只接受安非他明治疗的猫的视觉皮层消融显示出快速和持久的恢复，其中2只动物获得了仅在双眼视觉下观察到的表现水平，表明双眼深度知觉恢复。不对称病变的猫在安非他明治疗期间仅表现出短暂的改善，并且一些未显示安非他明中毒的自主体征的动物没有改善。盐水处理的猫没有表现出改善的迹象，安非他明的作用被阻断的儿茶酚胺能拮抗剂氟哌啶醇。这些结果表明，安非他明可以诱导脑损伤后的行为缺陷的持久恢复，如果不治疗，不会自发恢复。
After bilateral visual cortex ablation, cats exhibit a loss of depth perception as measured on a visual cliff, which recovers following administration of d-amphetamine. In this Study, 3 amphetamine-treated cats with visual cortex ablations showed a rapid and enduring recovery, with 2 of these animals obtaining levels of performance seen only with binocular vision, suggesting a restoration of binocular depth perception. Cats with asymmetrical lesions showed only a transient improvement during amphetamine treatment, and some animals not displaying autonomic signs of amphetamine intoxication did not improve. Saline-treated cats showed no signs of improvement, and the effect of amphetamine was blocked by the catecholaminergic antagonist haloperidol. These results indicate that amphetamine can induce an enduring recovery from a behavioral deficit after brain injury, which if left untreated would not spontaneously recover.