STUDIES IN CHRONIC ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS .1. CLINICAL AND PHYSIOLOGICAL FINDINGS
STUDIES IN CHRONIC ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS .1. CLINICAL AND PHYSIOLOGICAL FINDINGS
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DOI：
10.1136/thx.32.3.254
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发表时间：
1977-01-01
期刊：
影响因子：
10
通讯作者：
PEPYS, J
中科院分区：
文献类型：
--
作者：
MALO, JL;HAWKINS, R;PEPYS, J
本报告概述了 50 名患有慢性过敏性支气管肺曲霉病的哮喘患者的临床和生理特征，这些患者的诊断时间为 2-25 年前（平均病程 10.9 年）。通过问卷调查和对峰值呼气流速测量值的分析，发现冬季情况更糟，对应于大气中烟曲霉的最大浓度。 19 名患者报告每天产生的痰量高达 1 蛋杯或更多，其中 24 名患者在前一年发现痰塞。 20 名患者发现肺活量 (VC) 减少，38 名患者 1 秒用力呼气量 (FEV1) 减少，47 名患者 50% VC 呼吸空气时最大呼气流量 (.ovrhdot.V50air) 减少。九名患者的气体转移因子（DLCO）显着降低。仅 17 名患者在吸入支气管扩张剂后 FEV1 显着改善（超过 15%）。 VC、FEV1 和 ovrhdot.V50air 生理测量值的降低程度与研究时患者的年龄以及后来做出曲霉病诊断的年龄之间存在统计学上显着的相关性，而 DLCO 的降低也与曲霉病的持续时间显着相关。需要进行前瞻性研究，以正确评估治疗多年来对疾病引起的病理生理变化的保护作用。
This report outlines the clinical and physiological features in 50 asthmatic patients with chronic allergic bronchopulmonary aspergillosis in whom the diagnosis was made from 2-25 yr ago (mean duration 10.9 yr). From a questionnaire and analysis of the peak expiratory flow rate measurements, it was found that they were worse in the winter months, corresponding to the maximal concentrations of Aspergillus fumigatus in the atmosphere. Nineteen patients reported daily sputum production of up to an eggcupful or more, and 24 had noticed sputum plugs in the previous yr. Reduction of vital capacity (VC) was found in 20 patients, of forced expiratory volume in 1 s (FEV1) in 38 patients and of maximal expiratory flow at 50% VC breathing air (.ovrhdot.V50air) in 47 patients. Nine patients had significantly reduced gas transfer factor (DLCO). Significant improvement (more than 15%) in FEV1 after inhaled bronchodilator was shown by only 17 patients. There were statistically significant correlations between the degree of reduction in the physiological measurements of VC, FEV1, and .ovrhdot.V50air with the age of the patient at the time of the study and the later in life the diagnosis of aspergillosis was made, whereas the reduction in DLCO was also significantly related to the duration of aspergillosis. Prospective studies are needed for a proper assessment of any protective effect of treatment on the pathophysiological changes due to the disease over many yr.