Formative pluripotency: the executive phase in a developmental continuum.
Formative pluripotency: the executive phase in a developmental continuum.
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DOI：
10.1242/dev.142679
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发表时间：
2017-02-01
期刊：
影响因子：
--
通讯作者：
Smith A
中科院分区：
文献类型：
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作者：
Smith A
单细胞产生所有初级胚胎谱系的调节能力被称为多能性。观察波动的基因表达和表型异质性在体外培养的概念，多能性作为一个内在的亚稳态和不稳定的状态。然而，在胚胎和特定的培养环境中，多能细胞的特性以有序的顺序变化。先前已经描述了多能性的两个阶段，称为幼稚和引发。在这篇假说文章中，第三个阶段，称为形成性多能性，被认为是幼稚阶段和启动阶段之间发展连续体的一部分。假设形成阶段能够执行多能性，需要重塑转录，表观遗传，信号传导和代谢网络，以构成多谱系能力和对规格线索的响应。总结：这篇假说文章提出了多能性的第三种状态，称为形成性多能性，存在于幼稚状态和启动状态之间，并且能够执行多能性。
The regulative capability of single cells to give rise to all primary embryonic lineages is termed pluripotency. Observations of fluctuating gene expression and phenotypic heterogeneity in vitro have fostered a conception of pluripotency as an intrinsically metastable and precarious state. However, in the embryo and in defined culture environments the properties of pluripotent cells change in an orderly sequence. Two phases of pluripotency, called naïve and primed, have previously been described. In this Hypothesis article, a third phase, called formative pluripotency, is proposed to exist as part of a developmental continuum between the naïve and primed phases. The formative phase is hypothesised to be enabling for the execution of pluripotency, entailing remodelling of transcriptional, epigenetic, signalling and metabolic networks to constitute multi-lineage competence and responsiveness to specification cues. Summary: This Hypothesis article poses that a third state of pluripotency, called formative pluripotency, exists between the naïve and primed states, and is enabling for the execution of pluripotency.