Effects of hPTH(1-34) Infusion on Circulating Serum Phosphate, 1,25-Dihydroxyvitamin D, and FGF23 Levels in Healthy Men
Effects of hPTH(1-34) Infusion on Circulating Serum Phosphate, 1,25-Dihydroxyvitamin D, and FGF23 Levels in Healthy Men
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DOI：
10.1359/jbmr.090406
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发表时间：
2009-10-01
影响因子：
6.2
通讯作者：
Leder, Benjamin Z.
中科院分区：
文献类型：
--
作者：
Burnett-Bowie, Sherri-Ann M.;Henao, Maria P.;Leder, Benjamin Z.
成纤维细胞生长因子23（FGF 23）促进磷酸尿并抑制1，25-二羟维生素D [1，25（OH）（2）D]的产生。PTH也促进磷酸尿，但相反，刺激1，25（OH）（2）D的生产。FGF 23和PTH之间的关系尚不清楚，并且不知道高剂量PTH对FGF 23分泌的急性影响。20名健康男性以44 ng/kg/h输注人PTH（1 - 34）[hPTH（1-34）] 24 h。与基线相比，在1.8小时hPTH（1-34）输注期间，FGF 23、1，25（OH）（2）D、离子钙（伊卡）和血清N端肽（NTX）显著升高（p < 0.0001），而血清磷酸盐（PO（4））短暂升高，然后恢复至基线。FGF 23从基线时的35 +/- 10 pg/ml增加至18 h时的53 +/- 20 pg/ml（p = 0.0002）; 1，25（OH）（2）D从基线时的36 +/- 16 pg/ml增加至18 h时的80 +/- 33 pg/ml（p < 0.0001）;伊卡从基线时的1.23 +/- 0.03 mM增加到第18小时时的1.46 +/- 0.05 mM（p < 0.0001）; NTX从基线时的17 +/- 4 nM BCE增加至峰值时的28 +/- 8 nM BCE（P < 0.0001）基线时PO（4）为3.3 +/- 0.6 mg/dl，第6小时短暂升高至3.7 +/- 0.4 mg/dl（p = 0.016），然后在第12小时恢复至3.4 +/- 0.5 mg/dl（p = 0.651）。在健康男性中，hPTH（1-34）输注在18小时内增加内源性1，25（OH）（2）D和FGF 23。虽然PO（4）的升高可能有助于观察到的FGF 23的增加，但1，25（OH）（2）D的增加比血清磷酸盐的变化更显著且持续时间更长。鉴于之前的数据表明甲状旁腺激素和钙都不会刺激FGF 23的分泌，这些数据支持1，25（OH）（2）D是FGF 23分泌的有效生理刺激剂的说法。骨矿研究杂志2009;24：1681-1685。2009年4月27日在线发布; doi：10.1359/JBMR.090406
Fibroblast growth factor 23 (FGF23) promotes phosphaturia and suppresses 1,25-dihydroxyvitamin D [1,25(OH)(2)D] production. PTH also promotes phosphaturia, but, in contrast, stimulates 1,25(OH)(2)D production. The relationship between FGF23 and PTH is unclear, and the acute effect of pharmacologically dosed PTH on FGF23 secretion is unknown. Twenty healthy men were infused with human PTH(1-34) [hPTH(1-34)] at 44 ng/kg/h for 24 h. Compared with baseline, FGF23, 1,25(OH)(2)D, ionized calcium (iCa), and serum N-telopeptide (NTX) increased significantly over the 1.8-h hPTH(1-34) infusion (p < 0.0001), whereas serum phosphate (PO(4)) transiently increased and then returned to baseline. FGF23 increased from 35 +/- 10 pg/ml at baseline to 53 +/- 20 pg/ml at 18 h (p = 0.0002); 1,25(OH)(2)D increased from 36 +/- 16 pg/ml at baseline to 80 +/- 33 pg/ml at 18 h (p < 0.0001); iCa increased from 1.23 +/- 0.03 mM at baseline to 1.46 +/- 0.05 mM at hour 18 (p < 0.0001.); and NTX increased from 17 +/- 4 nM BCE at baseline to 28 +/- 8 nM BCE at peak (P < 0.0001) PO(4) was 3.3 +/- 0.6 mg/dl at baseline, transiently rose to 3.7 +/- 0.4 mg/dl at hour 6 (p = 0.016), and then returned to 3.4 +/- 0.5 mg/dl at hour 12 (p = 0.651). hPTH(1-34) infusion increases endogenous 1,25(OH)(2)D and FGF23 within 18 h in healthy men. Whereas it is possible that the rise in PO(4) contributed to the observed increase in FGF23, the increase in 1,25(OH)(2)D was more substantial and longer sustained than the change in serum phosphate. Given prior data that suggest that neither PTH nor calcium stimulate FGF23 secretion, these data support the assertion that 1,25(OH)(2)D is a potent physiologic stimulator of FGF23 secretion. J Bone Miner Res 2009;24:1681-1685. Published online on April 27, 2009; doi: 10.1359/JBMR.090406