ERP and behavioural evidence for direct suppression of unwanted memories
ERP and behavioural evidence for direct suppression of unwanted memories
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DOI：
10.1016/j.neuroimage.2009.06.051
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发表时间：
2009-12-01
期刊：
影响因子：
5.7
通讯作者：
Richardson-Klavehn, Alan
中科院分区：
文献类型：
--
作者：
Bergstroem, Zara M.;de Fockert, Jan W.;Richardson-Klavehn, Alan
有一些过去的经历，我们宁愿不记得。先前的研究表明，反复停止提取不需要的记忆会增加后来忘记该记忆的可能性，并使前额叶控制机制减弱海马体的活动。然而，阻止记忆提取的机制，以及这些机制与后来的遗忘的关系，尚未完全了解。在这里，我们提出的神经和行为的证据表明，两种不同的策略检索停止直接记忆抑制和自我分心的思想替代有助于忘记不必要的记忆在质量上不同的方式。只有直接的记忆抑制减少了中央-顶叶阳性的事件相关电位（ERP）之间的300和600毫秒刺激后，符合减少ERP相关的回忆。此外，只有直接记忆抑制产生了较晚的抑制性遗忘，这是由早期的负ERP效应预测的，可能与运动抑制有关。与此相反，思维替代产生较晚的非抑制性遗忘，并没有影响ERP相关的回忆。我们的研究结果表明，第一ERP和行为分离之间的抑制性和非抑制性遗忘，并建议，不需要的记忆可能会直接抑制没有选择性检索的替代记忆。(C)2009 Elsevier Inc. All rights reserved.
There are some past experiences that we would prefer not to remember. Previous research has shown that repeatedly stopping retrieval of an unwanted memory increases the probability of later forgetting of that memory, and engages prefrontal control mechanisms to attenuate activity in the hippocampus. However, the mechanisms of preventing memory retrieval, and how these relate to the later forgetting, are yet to be fully understood. Here we present neural and behavioural evidence that two distinct strategies for retrieval stopping-direct memory suppression and self-distracting thought substitution-contribute to forgetting of unwanted memories in qualitatively different ways. Only direct memory suppression reduced centro-parietal positivity in the event-related potentials (ERP) between 300 and 600 ms post-stimulus, consistent with a reduction in the ERP correlate of recollection. Furthermore, only direct memory suppression produced later inhibitory forgetting that was predicted by an earlier negative ERP effect that may be associated with motor inhibition. In contrast, thought substitution produced later non-inhibitory forgetting and had no effect on the ERP correlate of recollection. Our findings demonstrate the first ERP and behavioural dissociation between inhibitory and non-inhibitory forgetting, and suggest that unwanted memories may be directly suppressed without selective retrieval of alternative memories. (C) 2009 Elsevier Inc. All rights reserved.