Long-lasting effects of chemical hypoxia on spinal cord function in tadpoles.
Long-lasting effects of chemical hypoxia on spinal cord function in tadpoles.
复制标题
化学缺氧对蝌蚪脊髓功能的长期影响。
DOI：
10.1097/wnr.0b013e32833e332d
复制
发表时间：
2010
期刊：
影响因子：
1.7
通讯作者：
Robertson RM
中科院分区：
文献类型：
--
作者：
Robertson RM
我们研究了化学性低氧对非洲爪蟾42期幼虫控制游泳的中枢模式发生器的影响。我们记录了运动神经元活动的腹根固定蝌蚪和诱发游泳事件的尾部皮肤的短暂电刺激。在存在的代谢抑制剂，叠氮化钠（5 mM，NaN 3），游泳发作持续时间和周期频率下降，直到游泳运动模式不能被诱发。恢复后，周期频率恢复到叠氮片前水平;然而，发作持续时间仍然很短，至少1小时。此外，恢复诱导自发的，短暂的游泳类似的慢节奏，是由N-甲基-D-天冬氨酸诱发。我们的结论是，非生物特征的环境可以有长期的调节作用，在中枢神经系统的电路功能。
We investigated the effects of chemical hypoxia on the central pattern generator controlling swimming in stage 42 Xenopus laevis larvae. We recorded motoneuron activity from ventral roots of immobilized tadpoles and evoked swim episodes by brief electrical stimulation of the tail skin. In the presence of the metabolic inhibitor, sodium azide (5 mM, NaN 3), swim episode duration and cycle frequency decreased until swim motor patterns could not be evoked. On recovery, cycle frequency returned to preazide levels; however, episode duration remained short for at least an hour. In addition, recovery induced spontaneous, short bouts of swimming similar to the slow rhythm that is evoked by N-methyl-D-aspartic acid. We conclude that abiotic features of the environment can have long-term modulatory effects on circuit function in the CNS.