AGE-RELATED-CHANGES IN THE ULTRASTRUCTURE OF BRUCHS MEMBRANE
AGE-RELATED-CHANGES IN THE ULTRASTRUCTURE OF BRUCHS MEMBRANE
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DOI：
10.1016/0002-9394(85)90625-7
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发表时间：
1985-01-01
影响因子：
4.2
通讯作者：
ELLERSIECK, MR
中科院分区：
文献类型：
--
作者：
FEENEYBURNS, L;ELLERSIECK, MR
一项对68只人眼中布鲁赫膜的超微结构研究表明，黄斑样本的变化始于第二个十年，而非黄斑样本的变化则延迟。所有来自20岁捐赠者的标本都发生了黄斑布鲁赫膜的改变。变化的严重程度随着年龄的增长而增加。所有年龄段最常见的变化是弹性层两侧的碎片。玻璃疣部位通常在下方的外胶原区没有碎片，表明玻璃疣可能是由于这些部位积聚的物质分散失败所致。色素上皮分泌的“线性基底存款”是一种晚期（50岁以后）的变化。
An ultrastructural study of Bruch''s membrane in 68 human eyes including at least five individuals from each of ten decades of life showed that changes began in the second decade in macular specimens but were delayed in nonmacular specimens. All specimens from 20-year-old donors had altered macular Bruch''s membranes. The severity of changes increased with age. The most common change for all ages was debris on both sides of the elastic layer. Drusen sites often showed no debris in the underlysing outer collagenous zone, suggesting that drusen may result from failure of dispersal of the accumulated material at these sites. Secretion by pigment epithelium of a "linear basal deposit" is a late (after the age of 50 years) change.