Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats
Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats
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DOI：
10.1016/j.metabol.2013.12.004
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发表时间：
2014-04-01
影响因子：
9.8
通讯作者：
You, Tongjian
中科院分区：
文献类型：
--
作者：
Disanzo, Beth L.;You, Tongjian
Objective.探讨肥胖和运动训练对大鼠局部脂肪组织血管生成和缺氧标志物的影响。将2月龄的瘦（Fa/Fa）和肥胖（fa/fa）雄性Zucker大鼠随机分配到久坐组或运动训练组（瘦久坐组：n = 7，瘦运动组：n = 8，肥胖久坐组：n = 7，肥胖运动组：n = 8）。运动组在大鼠跑步机上行走，每周5次，共8周。测定腹股沟和附睾脂肪组织血管内皮生长因子A（VEGF-A）和乳酸水平。肥胖对腹股沟肌张力增高有显著影响（P
Objective. To investigate the effects of obesity and exercise training on regional adipose tissue angiogenesis and hypoxia markers in rats.Methods. Lean (Fa/Fa) and obese (fa/fa) male Zucker rats at 2 months of age were randomly assigned to a sedentary or an exercise training group (lean sedentary: n = 7, lean exercise: n = 8, obese sedentary: n = 7, obese exercise: n = 8). The exercise group walked on a rat treadmill 5 times per week for 8 weeks. Inguinal and epididymal adipose tissue vascular endothelial growth factor A (VEGF-A) and lactate levels were determined.Results. There were significant effects of obesity in increasing inguinal (P