Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.
Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.
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本体脊髓神经元对猴子皮质脊髓束损伤后手部灵活性恢复的贡献。
DOI：
10.1073/pnas.1610787114
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
T.
中科院分区：
文献类型：
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作者：
Tohyama;T.;Kinoshita;M.;Kobayashi;K.;Isa;K.;Watanabe;D.;Kobayashi;K.;Liu;M.;and Isa;T.
直接的皮质-运动神经元连接被认为是控制灵巧手运动所必需的，例如灵长类动物的精确抓握。然而，据报道，即使在C4-C5节段的皮质脊髓束（CST）损伤后，精确抓握也在1-3个月内基本恢复，这表明恢复取决于通过损伤吻侧的闰神经元（如中颈段的固有脊髓神经元（PN））的传递。为了获得直接证据的贡献PNs恢复后CST病变，我们应用了一种途径选择性和可逆的阻断方法，使用双病毒载体的PNs在6只猴子CST病变后，在C4-C5。在四只猴子，表现出几乎完全或部分恢复，短暂封锁PN传输后恢复造成部分损害的精确的抓地力。在另外两只猴子中，在持续整个术后观察期（3-4.5个月）的PN传输持续阻断下制作CST病变。在这些猴子中，未实现精确抓握恢复。这些结果提供了证据的因果关系的贡献PN恢复CST病变后的手灵活性; PN传输是必要的，以促进初始阶段的恢复，但是，他们的贡献是只有部分的恢复后实现。
The direct cortico-motoneuronal connection is believed to be essential for the control of dexterous hand movements, such as precision grip in primates. It was reported, however, that even after lesion of the corticospinal tract (CST) at the C4–C5 segment, precision grip largely recovered within 1–3 mo, suggesting that the recovery depends on transmission through intercalated neurons rostral to the lesion, such as the propriospinal neurons (PNs) in the midcervical segments. To obtain direct evidence for the contribution of PNs to recovery after CST lesion, we applied a pathway-selective and reversible blocking method using double viral vectors to the PNs in six monkeys after CST lesions at C4–C5. In four monkeys that showed nearly full or partial recovery, transient blockade of PN transmission after recovery caused partial impairment of precision grip. In the other two monkeys, CST lesions were made under continuous blockade of PN transmission that outlasted the entire period of postoperative observation (3–4.5 mo). In these monkeys, precision grip recovery was not achieved. These results provide evidence for causal contribution of the PNs to recovery of hand dexterity after CST lesions; PN transmission is necessary for promoting the initial stage recovery; however, their contribution is only partial once the recovery is achieved.