Mesothelin-family proteins and diagnosis of mesothelioma
Mesothelin-family proteins and diagnosis of mesothelioma
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DOI：
10.1016/s0140-6736(03)14794-0
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发表时间：
2003-11-15
期刊：
影响因子：
168.9
通讯作者：
Hellstrom, I
中科院分区：
文献类型：
--
作者：
Robinson, BWS;Creaney, J;Hellstrom, I
间皮瘤是一种高度侵袭性的肿瘤，目前尚无可靠的血清肿瘤标志物。标记。这种标志物的鉴定将有助于间皮瘤的诊断和监测治疗反应和筛选高危个体。在来自44名经组织学证实的间皮瘤患者的血清样品的盲法研究中的（夹心）ELISA; 68名匹配的健康对照者，其中40人曾接触石棉;结果44例间皮瘤患者中有37例（84%）在血清稀释度为1/80时SMR浓度升高，与此相比，160名患有其他癌症或其他炎症性肺部或胸膜疾病的患者中有3人（2%），而28名未接触石棉的对照组中没有人。SMR浓度与肿瘤大小相关，并在肿瘤进展期间增加。40名接触石棉的人中有7人血清SMR浓度升高;其中3人在1-5年内发展为间皮瘤，1人发展为肺癌。33例血清SMR浓度正常的石棉接触者中无一例发生间皮瘤，随访8年以上，血清SMR测定可作为诊断间皮瘤和监测疾病进展的有用指标。它也可能被证明有助于筛选石棉暴露的个人间皮瘤的早期证据。
Background Mesothelioma is a highly aggressive tumour for which there are no reliable serum tumour. markers. Identification of such a marker would be useful in diagnosis of mesothelioma and for monitoring responses to treatment and screening at-risk individuals.Methods We assayed serum concentrations of soluble mesothelin-related proteins (SMR) using a double determinant (sandwich) ELISA in a blinded study of serum samples from 44 patients with histologically proven mesothelioma; 68 matched healthy controls, 40 of whom had been exposed to asbestos; and 160 patients with other inflammatory or malignant lung and pleural diseases.Findings 37 (84%) of 44 patients with mesothelioma had raised concentrations of SMR at a serum dilution of 1/80, compared with three (2%) of 160 patients with other cancers or other inflammatory lung or pleural diseases, and with none of 28 controls who had not been exposed to asbestos. SMR concentrations correlated with tumour size and increased during tumour progression. Seven of the 40 asbestos-exposed individuals had increased serum concentrations of SMR; three of those seven developed mesothelioma and one developed lung carcinoma within 1-5 years. None of the 33 asbestos-exposed participants whose serum samples had normal concentrations of SMR and who were followed up over 8 years developed mesothelioma.Interpretation Determination of SMR in serum could be a useful marker for diagnosis of mesothelioma and to monitor disease progression. It might also prove helpful for screening asbestos-exposed individuals for early evidence of mesothelioma.