New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft.
New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft.
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DOI：
10.3390/md15010019
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发表时间：
2017-01-18
期刊：
影响因子：
5.4
通讯作者：
Al-Harrasi A
中科院分区：
文献类型：
--
作者：
Ali L;Khan AL;Al-Broumi M;Al-Harrasi R;Al-Kharusi L;Hussain J;Al-Harrasi A
在继续我们的研究的化学和生物学潜力的次级代谢产物分离出的阿曼海藻，我们调查了一个海洋棕色的，Padina boergesenii。植物化学的研究导致了一个新的次级代谢产物的分离，派丁醇酸（1），沿着一些其他的半纯级分和亚级分。平面结构通过MS和NMR（1D和2D）光谱数据确认。NOESY实验结合生物遗传学考虑有助于分配分子中的立体化学。使用尿素酶、脂质过氧化物酶和α-葡糖苷酶对化合物1进行酶抑制研究。化合物1对α-葡萄糖苷酶和尿素酶分别表现出低至中度的抑制作用，并表现出中度的抗脂质过氧化活性。目前的研究表明，这种海藻的潜力，并提供了进一步调查的基础。
In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound 1 was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound 1 showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation.