Prospective screening in familial nonmedullary thyroid cancer.
Prospective screening in familial nonmedullary thyroid cancer.
复制标题
家族性非髓样甲状腺癌的前瞻性筛查。
DOI：
10.1016/j.surg.2013.06.019
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发表时间：
2013
期刊：
影响因子：
3.8
通讯作者：
Kebebew,Electron
中科院分区：
文献类型：
--
作者：
Sadowski,SamiraM;He,Mei;Gesuwan,Krisana;Gulati,Neelam;Celi,Francesco;Merino,MariaJ;Nilubol,Naris;Kebebew,Electron
大约8%的非髓样甲状腺癌是家族性的。筛选在家族性非髓样甲状腺癌（FNMTC）的最佳年龄是unknow.MethodsKinnases与FNMTC（2个或更多的一级亲属影响）进行了前瞻性的筛选与甲状腺ultrasonography. Results15 kinnases显示的总体患病率甲状腺结节（S）≥5毫米的44%，在筛选，19%的第二代，90%的代前的索引情况下。发现甲状腺结节的最小年龄为10岁，发现甲状腺癌的最小年龄为18岁。筛查时甲状腺结节的微钙化与更高的癌症风险相关（P<0.05）。超声筛查诊断为甲状腺癌的家庭成员被诊断为在较年轻的年龄，并有较低的甲状腺外侵犯率（P<0.05）。结论在FNMTC，一级亲属10岁或以上，包括前一代的索引情况下，应该有甲状腺超声筛查，这可能会导致早期诊断。
BackgroundApproximately 8% of nonmedullary thyroid cancers are familial. The optimal age for screening in familial nonmedullary thyroid cancer (FNMTC) is unknown.MethodsKindreds with FNMTC (2 or more first-degree relatives affected) were screened prospectively with thyroid ultrasonography.ResultsFifteen kindreds showed an overall prevalence of thyroid nodule(s) ≥5 mm of 44% at screening; 19% in the second generation, and 90% in the generation anterior to the index case. The youngest age of detection was 10 years for thyroid nodules and 18 years for thyroid cancer. Microcalcification of thyroid nodules at screening was associated with a greater risk of cancer (P< .05). Family members diagnosed with thyroid cancer by ultrasonographic screening were diagnosed at a younger age and had a lower rate of extra thyroidal invasion (P< .05).ConclusionIn FNMTC, first-degree relatives 10 years or older, including the generation anterior to the index case, should have thyroid screening by ultrasonography, which may result in earlier diagnosis.