Epidemiology and Clinical Research Design, Part 1: Study Types.
Epidemiology and Clinical Research Design, Part 1: Study Types.
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DOI：
10.1542/neo.15-12-e558
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发表时间：
2014-12-01
期刊：
影响因子：
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通讯作者：
Lakshminrusimha S
中科院分区：
文献类型：
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作者：
Manja V;Lakshminrusimha S
选择最佳的预防和治疗措施，以避免残疾和死亡是所有卫生保健从业人员的一个重要目标。为了实现这一目标，我们需要进行研究，确定这些措施的价值。在这篇文章中，我们讨论了可能的研究设计，可用于评估新的预防和治疗方法。金标准研究设计是一项随机、对照、双盲试验。在许多情况下，随机对照试验可能在伦理上或实际上不可行。可能需要其他研究类型，如病例系列、病例对照研究、队列研究、横断面研究、交叉设计和开放标签研究，以假设和评价暴露或预测变量与结局变量之间的联系。本文综述了有关围产医学的各种研究类型。
Selecting the best available preventive and therapeutic measures to avoid disability and death is an important goal for all health care practitioners. To achieve this goal, we need to perform studies that determine the value of these measures. In this article, we discuss the possible study designs that can be used for evaluating new approaches to prevention and treatment. The gold standard study design is a randomized, controlled, double-blind trial. In many instances, a randomized controlled trial may not be ethically or practically feasible. Other study types, such as case series, case-control studies, cohort studies, cross-sectional studies, crossover designs, and open-label studies, may be required to hypothesize and evaluate the link between an exposure or predictor variable and an outcome variable. Various study types pertaining to neonatal-perinatal medicine are reviewed in this article.