Be Easy and Chill: Melanoma Cells Tell Lymph Node Fibroblasts to Relax.
Be Easy and Chill: Melanoma Cells Tell Lymph Node Fibroblasts to Relax.
复制标题
放松心情：黑色素瘤细胞告诉淋巴结成纤维细胞放松。
DOI：
10.1158/0008-5472.can-22-0940
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发表时间：
2022
期刊：
影响因子：
11.2
通讯作者：
Lund,AmandaW
中科院分区：
文献类型：
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作者：
Lund,AmandaW
黑色素瘤利用肿瘤引流淋巴结来支持转移潜能并安装免疫抑制剂。然而，介导淋巴结教育的具体机制仍不完全清楚。在这个问题上，Rovera和他的同事描述了去分化的黑色素瘤细胞使收缩性淋巴结成纤维细胞失活，导致淋巴结扩张和增强黑色素瘤侵袭潜力。成纤维细胞网状细胞松弛依赖于对组成性JAK 1/STAT 3和雅普/TAZ信号传导的抑制，其部分由炎性细胞因子IL 1的肿瘤分泌介导。这些数据支持一种新的假设，即内在的黑色素瘤异质性向前推动微环境适应，介导侵袭和进展。第1774页
Melanomas coopt tumor-draining lymph nodes to support metastatic potential and install immunosuppression. The specific mechanisms that mediate lymph node education, however, remain incompletely understood. In this issue, Rovera and colleagues describe the deactivation of contractile lymph node fibroblasts by dedifferentiated melanoma cells, leading to lymph node expansion and enhanced melanoma invasive potential. Fibroblastic reticular cell relaxation depended upon inhibition of constitutive JAK1/STAT3 and YAP/TAZ signaling, which was mediated in part by tumor secretion of the inflammatory cytokine, IL1. These data support an emerging hypothesis that intrinsic melanoma heterogeneity feeds forward to drive microenvironmental adaptations that mediate invasion and progression.See related article by Rovera et al., p. 1774