Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension
Ethnic origin determines the impact of genetic variants in dopamine receptor gene (DRD1) concerning essential hypertension
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DOI：
10.1016/j.amjhyper.2004.07.013
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发表时间：
2004-12-01
影响因子：
3.2
通讯作者：
Gessner, R
中科院分区：
文献类型：
--
作者：
Beige, J;Bellmann, A;Gessner, R
多巴胺受体1型(DRD1)与人类高血压的发生和自发性高血压的动物模型有关。我们筛选了人类DRD1受体的整个编码区和启动子区域的多态，以分析它们与高血压的关系。对493例高血压病患者和209例正常血压者进行了A-48G和G-94A两个常见单核苷酸多态的等位基因频率检测。两组间等位基因频率差异无统计学意义(高血压组-48 G等位基因=0.37；正常血压组-48 G等位基因=0.36；高血压组-94 A等位基因=0.14；正常血压组-94 A等位基因=0.10)。我们在这些高加索患者中的发现与日本最近的一项研究形成了鲜明对比，该研究显示-48G等位基因与高血压存在显著关联。因此，种族差异可能在多巴胺受体1型基因变异与原发性高血压的关联中发挥重要作用。(C)2004年美国高血压杂志有限公司。
The dopamine receptor type 1 (DRD1) has been implicated in the development of hypertension in humans as well as in animal models of spontaneous hypertension. We screened the entire coding and promoter region of the human DRD1 receptor for polymorphisms to analyze their association with hypertension. The allele frequencies of two common single-nucleotide polymorphisms, A-48G and G-94A were determined in 493 hypertensive patients and 209 normotensive controls. Allele frequencies did not differ for both polymorphisms between the two groups (-48 G-allele in hypertension = 0.37; -48 G-allele in normotension = 0.36; -94 A-allele in hypertension = 0.14; -94 A-allele in normotension = 0.10). Our findings in these Caucasian patients are in contrast to a recent Japanese study that revealed a significant association of the -48 G-allele with hypertension. Thus, racial differences may play an important role concerning the association of variants in the dopamine receptor type 1 gene with essential hypertension. (C) 2004 American Journal of Hypertension, Ltd.