Crossed cerebellar diaschisis:: a positron emission tomography study with L-[methyl-11C]methionine and 2-deoxy-2-[18F]fluoro-D-glucose
Crossed cerebellar diaschisis:: a positron emission tomography study with L-[methyl-11C]methionine and 2-deoxy-2-[18F]fluoro-D-glucose
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DOI：
10.1007/bf03033988
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发表时间：
2007-02-01
影响因子：
2.6
通讯作者：
Hatazawa, Jun
中科院分区：
文献类型：
--
作者：
Kajimoto, Katsufumi;Oku, Naohiko;Hatazawa, Jun
目的：交叉性小脑神经联系不能（CCD）是指通过正电子发射断层扫描（PET）和单光子发射计算机断层扫描检测到的幕上脑病变对侧小脑血流和葡萄糖氧化代谢的抑制。我们研究了L-[甲基-（11）C]蛋氨酸（MET）的摄取是否受到CCD的影响。研究方法：在12例单侧幕上脑肿瘤患者中，我们通过PET评估了小脑半球2-脱氧-2-[（18）F]氟-D-葡萄糖（FDG）和MET的摄取。不对称指数（AI）定义为同侧和对侧小脑半球平均计数的差异除以两侧小脑半球的平均计数。FDG PET的AI大于0.1和AI等于0.1或小于0.1的患者分别被分类为CCD阳性和CCD阴性。结果：在FDG PET研究中，6例患者为CCD阳性，其他患者为CCD阴性。在CCD阳性和CCD阴性患者之间，MET的平均AI无显著差异（分别为0.017 +/- 0.023和0.014 +/- 0.039）。结论：与糖代谢不同，CCD小脑MET摄取不受影响。本研究可能表明，小脑MET摄取是独立的小脑神经元活动的抑制。
Objective: Crossed cerebellar diaschisis (CCD) is defined as a depression of blood flow and oxidative metabolism of glucose in the cerebellum contralateral to a supratentorial brain lesion, as detected with positron emission tomography (PET) and single photon emission computed tomography. We examined whether L-[methyl-(11)C]methionine (MET) uptake is affected in CCD. Methods: In 12 patients with a unilateral supratentorial brain tumor, we evaluated the uptake of 2-deoxy-2-[(18)F]fluoro-D-ghlcose (FDG) and MET in the cerebellar hemispheres by means of PET. Asymmetry index (AI) was defined as a difference in the average count between the ipsilateral and contralateral cerebellar hemispheres divided by the average count in both cerebellar hemispheres. Patients with AI of FDG PET more than 0.1 and those with AI equal to 0.1 or less than 0.1 were classified as CCD-positive and CCD-negative, respectively. Results: Six patients were CCD-positive and others were CCD-negative in the FDG PET study. Between CCD-positive and CCD-negative patients, mean AI of MET was not significantly different (0.017 +/- 0.023 and 0.014 +/- 0.039, respectively). Conclusions: Different from glucose metabolism, cerebellar MET uptake was not affected in CCD. The present study may indicate that cerebellar MET uptake is independent of suppression of cerebellar neuronal activity.