Development and validation of a discriminative quality of life questionnaire for osteoporosis (the OPTQoL)
Development and validation of a discriminative quality of life questionnaire for osteoporosis (the OPTQoL)
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DOI：
10.1359/jbmr.1997.12.3.456
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发表时间：
1997-03-01
影响因子：
6.2
通讯作者：
Holmes, R
中科院分区：
文献类型：
--
作者：
Lydick, E;Zimmerman, SI;Holmes, R
我们报告了一个以骨质疏松症为目标的生活质量问卷的开发和验证，以衡量该疾病对普通人群的影响，从骨质疏松症女性，骨质疏松症风险的健康女性，骨质疏松症女性的配偶和亲属以及医疗保健提供者的多个焦点小组中，我们确定了300多个与该疾病相关的潜在项目，一份冗长的调查问卷包含了这些项目，并对第二个大型研究队列的222名临床骨质疏松症妇女进行了调查（骨折史、显著高度丢失和/或脊柱后凸）; 101名已知骨矿物质密度水平低的妇女，将其归类为骨质疏松症，但尚未表现出明显的疾病身体表现;和142名患有其他疾病的妇女（如关节炎、癌症、抑郁症），从最初的300个项目中选择最终项目，以证明其与骨质疏松症的关系，如通过临床表现和低骨密度测量的，以及与通过标准通用问卷测量的生活质量的关系，SF-36，最终问卷包括三个领域的26个评分项目-体力活动，适应和恐惧-和6个与疾病变化和诊断相关的未评分问题。这一工具在针对艾滋病的调查表中是独一无二的，因为它试图衡量该疾病在一个时间点对人口生活质量的总体影响。
We report the development and validation of an osteoporosis-targeted quality of life questionnaire to measure the impact of the disease in the general population, From multiple focus groups with women with osteoporosis, healthy women at risk for osteoporosis, spouses and relatives of women with osteoporosis, and health care providers, we identified over 300 potential items related to the disease, A lengthy questionnaire incorporated these items and was administered to a second large study cohort of 222 women with clinical osteoporosis (history of fracture, significant height loss, and/or kyphosis); 101 women with known low bone mineral density levels that would categorize them as osteoporotic but who had not yet shown obvious physical manifestations of the disease; and 142 women with other conditions (such as arthritis, cancer, depression) expected to also have an impact on quality of life, Final items from among the original 300 were chosen for their demonstrated relationship with osteoporosis as measured by clinical manifestations and low bone density and with quality of life measured by a standard generic questionnaire, the SF-36, The final questionnaire contains 26 scored items in three domains-physical activity, adaptations, and fears-and six nonscored questions relating to osteoporotic changes and diagnosis. This instrument is unique among osteoporosis-targeted questionnaires in that it attempts to measure the total impact of the disease on quality of life within a population at a single point in time.