Patients' perceptions of quality of life after treatment for early prostate cancer
Patients' perceptions of quality of life after treatment for early prostate cancer
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DOI：
10.1200/jco.2003.02.115
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发表时间：
2003-10-15
影响因子：
45.3
通讯作者：
Talcott, JA
中科院分区：
文献类型：
--
作者：
Clark, JA;Inui, TS;Talcott, JA
目的：早期前列腺癌的治疗会产生有问题的身体副作用，但先前的研究发现对患者的健康状况影响不大。我们研究了心理社会治疗的结果为早期prostate cancer.Patients和方法：以前治疗的前列腺癌患者和一个参考组的男性前列腺特异性抗原（PSA）水平正常，没有前列腺癌的历史完成了问卷调查。创新量表评估了泌尿功能障碍，性行为，健康担忧，PSA关注，感知癌症控制，治疗决策，决策后悔和癌症相关前景的行为后果。泌尿，肠道，性功能障碍进行了评估，症状指数;健康状况进行了评估的身心简表（SF-12）健康Surveillance.Results摘要：与男性相比，没有前列腺癌，前列腺癌患者报告更大的泌尿，肠道，性功能障碍，但相似的健康状况。他们报告了更严重的问题，尿控制，性亲密和信心，和男子气概，和更大的PSA关注。对癌症控制和治疗决策的看法是积极的，但治疗不同：直肠切除术患者表示最高，观察患者表示最低的癌症控制。肠道和性功能障碍与较差的性亲密，男子气概，并认为癌症控制;男子气概和PSA的关注与更大的信心，在治疗选择;和减少性亲密和PSA的兴趣减少与更大的regret.Conclusion：缺乏变化的全球措施的健康状况治疗后的早期前列腺癌掩盖了重要的影响，在男性的生活;癌症诊断和治疗并发症可能导致复杂的结果。积极的治疗可能会给癌症控制带来信心，但却会被伴随性功能障碍的亲密关系和男子气概的减少所抵消。(C)2003年，美国临床肿瘤学会。
Purpose: Treatment for early prostate cancer produces problematic physical side effects, but prior studies have found little influence on patients' perceived health status. We examined psychosocial outcomes of treatment for early prostate cancer.Patients and Methods: Patients with previously treated prostate cancer and a reference group of men with a normal prostate-specific antigen (PSA) level and no history of prostate cancer completed questionnaires. Innovative scales assessed behavioral consequences of urinary dysfunction, sexuality, health worry, PSA concern, perceived cancer control, treatment decision making, decision regret, and cancer-related outlook. Urinary, bowel, and sexual dysfunction were assessed with symptom indexes; health status was assessed by the Physical and Mental Summaries of the Short Form (SF-12) Health Survey.Results: Compared with men without prostate cancer, prostate cancer patients reported greater urinary, bowel, and sexual dysfunction, but similar health status. They reported worse problems of urinary control, sexual intimacy and confidence, and masculinity, and greater PSA concern. Perceptions of cancer control and treatment decisions were positive, but varied by treatment: prostatectomy patients indicated the highest and observation patients indicated the lowest cancer control. Bowel and sexual dysfunction were associated with poorer sexual intimacy, masculinity, and perceived cancer control; masculinity and PSA concern were associated with greater confidence in treatment choice; and diminished sexual intimacy and less interest in PSA were associated with greater regret.Conclusion: The lack of change in global measures of health status after treatment for early prostate cancer obscures important influences in men's lives; cancer diagnosis and treatment complications may result in complex outcomes. Aggressive treatment may confer confidence in cancer control, yet be countered by diminished intimate relationships and masculinity, which accompany sexual dysfunction. (C) 2003 by American Society of Clinical Oncology.