Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice
Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice
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DOI：
10.1271/bbb.70378
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发表时间：
2007-10-01
影响因子：
1.6
通讯作者：
Ono, Kazuhisa
中科院分区：
文献类型：
--
作者：
Onishi, Nobukazu;Kawamoto, Seiji;Ono, Kazuhisa
魔芋是一种具有独特质地的传统日本食品，它的主要成分魔芋葡甘露聚糖（KGM）可以改善代谢紊乱，如糖尿病和高胆固醇血症。我们发现用KGM粉（PKGM）喂养可以预防特应性皮炎小鼠模型的皮肤炎症。在这里，我们发现膳食PKGM在免疫和卵清蛋白（OVA）鼻致敏后抑制小鼠变应性鼻炎样症状。喂食pkgm的老鼠打喷嚏的频率比对照组的老鼠低得多。我们还发现，补充PKGM只抑制ova特异性IgE反应，而不影响lgG1/IgG2a反应以及全身Th1/Th2细胞因子的产生。这些结果表明，PKGM可能是一种有益的食物，可以预防鼻腔过敏，如季节性花粉症。
Konjac is a traditional Japanese food with a peculiar texture, and it has been suggested that its main ingredient, konjac glucomannan (KGM), ameliorates metabolic disorders such as diabetes and hypercholesteremia. We have found that feeding with pulverized KGM (PKGM) prevents skin inflammation in a murine model of atopic dermatitis. Here, we show that dietary PKGM suppresses allergic rhinitis-like symptoms in mice upon immunization and nasal sensitization with ovalbumin (OVA). The PKGM-fed mice showed a much lower frequency of sneezing than in control animals. We also found that PKGM supplementation exclusively suppressed OVA-specific IgE response without affecting lgG1/IgG2a responses as well as systemic Th1/Th2 cytokine production. These results suggest that PKGM can be a beneficial foodstuff in preventing nasal allergy such as seasonal pollinosis.