Differential expression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma
Differential expression of osteopontin and bone sialoprotein in bone metastasis of breast and prostate carcinoma
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DOI：
10.1023/a:1025419708343
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发表时间：
2003-01-01
影响因子：
4
通讯作者：
Andersson, G
中科院分区：
文献类型：
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作者：
Carlinfante, G;Vassiliou, D;Andersson, G
乳腺癌和前列腺癌经常向骨骼转移。有趣的是，这两种癌症类型引起的骨骼病变的组织病理学特征不同。乳腺肿瘤在骨骼中产生转移，并具有混合的裂解/硬化性模式，而在前列腺肿瘤的转移酶中，主要的硬化模式可见。骨桥蛋白（OPN）和骨唾液酸蛋白（BSP）是骨基质蛋白，与癌细胞的选择性亲和力有关。在本研究中，通过免疫组织化学研究了21例患有骨骼转移的患者病例及其各自的原发性肿瘤（12例乳腺癌，9例前列腺癌），以评估OPN和BSP的水平。在所有乳腺肿瘤的42％和所有前列腺肿瘤的56％中发现了中度至强的OPN表达。与前列腺肿瘤骨转移相比，乳腺癌骨转移量更高的乳腺癌骨转移表现高83％，11％（p = 0.0019）。相反，在33％的乳腺肿瘤和89％的前列腺肿瘤中发现了中度至强的BSP表达。在骨骼病变中，与100％的前列腺肿瘤转移相比，只有33％的乳腺肿瘤转移表达中等/强的BSP表达（P = 0.0046）。 OPN/BSP表达的这种不同模式可能是这两种类型的骨转移的不同特征的重要决定因素，即裂解与硬化性，与OPN在分化和激活骨质细胞和BSP的激活中所提出的作用一致骨矿化的刺激剂。
Breast and prostate cancer often metastasise to the skeleton. Interestingly, the histopathological characteristics of the bone lesions that arise from these two cancer types differ. Breast tumours give rise to metastases in the skeleton with a mixed lytic/sclerotic pattern, whereas a predominantly sclerotic pattern is seen in metastases from prostate tumours. Osteopontin (OPN) and bone sialoprotein (BSP) are bone matrix proteins that have been implicated in the selective affinity of cancer cells for bone. In the present study, 21 patient cases with skeletal metastasis and their respective primary tumours ( 12 with breast cancer, 9 with prostate cancer) were investigated by immunohistochemistry in order to assess the level of OPN and BSP. Moderate to strong OPN expression was found in 42% of all breast tumours and in 56% of all prostate tumours. Significantly more breast cancer bone metastases exhibited high OPN expression, 83%, as compared with prostate tumour bone metastases, 11% ( P = 0.0019). In contrast, moderate to strong BSP expression was found in 33% of breast tumours and in 89% of prostate tumours. In the bone lesions, only 33% of breast tumour metastases showed moderate/strong BSP expression compared to 100% of prostate tumour metastases ( P = 0.0046). This divergent pattern of OPN/BSP expression could be an important determinant for the different characteristics of these two types of bone metastasis, i.e., lytic vs. sclerotic, consistent with the proposed role of OPN in differentiation and activation of osteoclasts and of BSP as a stimulator of bone mineralisation.