Plasma Apolipoprotein L1 Levels Do Not Correlate with CKD
Plasma Apolipoprotein L1 Levels Do Not Correlate with CKD
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DOI：
10.1681/asn.2013070700
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发表时间：
2014-03-01
影响因子：
13.6
通讯作者：
Kalayjian, Robert C.
中科院分区：
文献类型：
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作者：
Bruggeman, Leslie A.;O'Toole, John F.;Kalayjian, Robert C.
APOL1多态性与非洲血统个体的CKD（包括HIV相关CKD）相关。载脂蛋白L1（APOL1）蛋白循环并定位于肾细胞中，但APOL1位置对CKD发病机制的贡献尚不清楚。我们在一项多中心前瞻性观察性研究中对270例HIV感染的非裔美国人进行了巢式病例对照研究，研究了血浆APOL1水平与血浆细胞因子水平、血脂异常和APOL1基因型的相关性。当估计的GFR（eGFR）降低至
Polymorphisms in APOL1 are associated with CKD, including HIV-related CKD, in individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is localized in kidney cells, but the contribution of APOL1 location to CKD pathogenesis is unclear. We examined associations of plasma APOL1 levels with plasma cytokine levels, dyslipidemia, and APOL1 genotype in a nested case-control study (n=270) of HIV-infected African Americans enrolled in a multicenter prospective observational study. Patients were designated as having CKD when estimated GFR (eGFR) decreased to