Scratching behavior in various strains of mice
Scratching behavior in various strains of mice
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DOI：
10.1159/000056338
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发表时间：
2001-03-01
期刊：
影响因子：
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通讯作者：
Nagai, H
中科院分区：
文献类型：
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作者：
Inagaki, N;Nagao, M;Nagai, H
对12个品系的小鼠进行抽搐行为的诱导，并比较其频率。注射50 nmol组胺仅在ICR小鼠中引起频繁的抓挠行为，尽管相同剂量的5-羟色胺在除A/J外的所有品系小鼠中引起频繁的抓挠行为。组胺（10 nmol）、5-羟色胺（1 nmol）、P物质（50 nmol）和被动皮肤过敏反应在BALB/c、ICR、ddY和NC/Nga小鼠中引起显著的血管通透性增加。这四种刺激也诱导ICR小鼠频繁的抓挠行为。然而，它们未能诱导其他三种菌株的抓挠发生率大幅增加，除了ddY，其对P物质注射表现出轻微但显著的增加。这些结果表明，ICR小鼠对各种刺激，特别是对组胺的抓挠行为是一个很好的反应。因此，ICR小鼠可能适合于研究瘙痒的介质和/或机制。版权所有（C）2001 S. Karger AG，巴塞尔。
Scratching behavior was induced in 12 strains of mice and the frequency was compared. An injection of histamine at a dose of 50 nmol induced frequent scratching behavior only in ICR mice, although the same dose of serotonin induced frequent scratching behavior in all strains of mice except for A/J. Histamine (10 nmol), serotonin (1 nmol), substance P (50 nmol) and passive cutaneous anaphylaxis induced significant vascular permeability increase in BALB/c, ICR, ddY and NC/Nga mice. These four stimuli also induced frequent scratching behavior in ICR mice. However, they failed to induce substantial increase in the incidence of scratching in the other three strains, except for ddY, which exhibited a slight but significant increase against substance P injection. These results suggest that the ICR mouse is a good responder for scratching behavior against various stimuli, especially against histamine. Thus ICR mice may be suitable for studying mediators and/or mechanisms for itching. Copyright (C) 2001 S. Karger AG, Basel.