SYMPATHETIC ACTIVITY AND BLOOD-PRESSURE INCREASES WITH BLADDER DISTENSION IN HUMANS
SYMPATHETIC ACTIVITY AND BLOOD-PRESSURE INCREASES WITH BLADDER DISTENSION IN HUMANS
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DOI：
10.1161/01.hyp.14.5.511
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发表时间：
1989-11-01
期刊：
影响因子：
8.3
通讯作者：
KARHUVAARA, S
中科院分区：
文献类型：
--
作者：
FAGIUS, J;KARHUVAARA, S
对16名健康志愿者在生理性膀胱扩张过程中腓神经的交感神经活动进行了神经电图记录。当排尿的冲动明显时，交感神经流出从基线水平16.3 ±-增加。1.7至23.2 .+-。1.9爆发/分钟（平均值±. SEM，p < 0.01）。收缩压和舒张压都伴随着显著的升高，从125 ± 0.5。2/74 .+-. 2到140 .+-. 4/84 .+-. 3毫米汞柱。排尿后，交感神经活动和血压恢复到初始值。结论是：1）交感神经流出增加导致血压升高，2）在人类中存在由交感血管收缩神经元介导的膀胱血管反应，其对应于在动物中观察到的机制，和3）所描述的膀胱扩张和交感血管收缩活性之间的功能关系可能在临床病症中起作用病变和夜间排尿性晕厥。
Microneurographic recordings of muscle nerve sympathetic activity, which is governed by baroreceptors and involved in blood pressure regulation, were made in the peroneal nerve in 16 healthy volunteers during physiological bladder distension. When the urge to urinate was pronounced, sympathetic outflow increased from a baseline level of 16.3 .+-. 1.7 to 23.2 .+-. 1.9 bursts/min (mean .+-. SEM, p < 0.01). There was a concomitant significant rise in both systolic and diastolic blood pressure, from 125 .+-. 2/74 .+-. 2 to 140 .+-. 4/84 .+-. 3 mm Hg. After micturition, sympathetic activity and blood pressure returned toward initial values. It is concluded that 1) increased sympathetic outflow contributed to the rise in blood pressure, 2) there is a vesicovascular response mediated by sympathetic vasoconstrictor neurons in humans corresponding to mechanisms observed in animals, and 3) the described functional relation between bladder distension and sympathetic vasoconstrictor activity probably plays a role in clinical conditions such as autonomic dysreflexia in humans with cervical spinal cord lesions and nocturnal micturition syncope.