Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma
Tumor volume as an independent predictive factor of worse survival in patients with oral cavity squamous cell carcinoma
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DOI：
10.1002/hed.24714
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发表时间：
2017-05-01
影响因子：
2.9
通讯作者：
Cernea, Claudio Roberto
中科院分区：
文献类型：
--
作者：
Lin, Chin Shien;de Oliveira Santos, Andre Bandiera;Cernea, Claudio Roberto
背景本研究的目的是探讨肿瘤体积在口腔鳞状细胞癌（SCC）患者预后中的作用。原发癌的体积计算的3个宏观尺寸的手术标本的乘法和相关的复发和death.ResultsThere有54复发（43.9%）和75死亡（60.9%）。在随访期间，无疾病患者的平均肿瘤体积为28.2 cc，而有疾病患者为88.2 cc，死于疾病的患者为78.9 cc（p <0.001）。多因素分析显示，体积和神经周围浸润是复发的独立因素，而体积和淋巴结转移是死亡的独立因素。(c)2017 Wiley Periodicals，Inc.头颈部39：960-964，2017
BackgroundThe purpose of the present study was to investigate the role of tumor volume in the prognosis of patients with oral cavity squamous cell carcinoma (SCC).MethodsOne hundred twenty-three patients with T4a oral cavity SCCs underwent surgical treatment. The volumes of the primary cancer were calculated by the multiplication of 3 macroscopic dimensions of the surgical specimen and related to recurrence and death.ResultsThere were 54 recurrences (43.9%) and 75 deaths (60.9%). The mean tumor volume among the patients living without disease during the follow-up period was 28.2 cc, compared to 88.2 cc for patients living with disease, and to 78.9 cc for patients who died of the disease (p < .001). Multivariate analyses showed that volume and perineural invasion were independent factors for recurrence, whereas volume and lymph node metastasis were independent factors for death.ConclusionAmong patients who already have advanced cancers, tumor volume can significantly impact their prognoses. (c) 2017 Wiley Periodicals, Inc. Head Neck 39: 960-964, 2017