Low levels of serum calcidiol in an African population compared to a North European population
Low levels of serum calcidiol in an African population compared to a North European population
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DOI：
10.1530/eje.0.1410358
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发表时间：
1999-10-01
影响因子：
5.8
通讯作者：
Falch, JA
中科院分区：
文献类型：
--
作者：
Feleke, Y;Abdulkadir, J;Falch, JA
目的：比较生活在10度N的非洲人群与生活在60度N的挪威人群的维生素D状况。设计：9月收集来自阿迪斯的30名健康年轻人和31名足月孕妇的血清样本，3月收集来自24名健康挪威人的血清样本，2月至6月收集来自奥斯陆的23名孕妇的血清样本。结果：与挪威人相比，挪威人的s-骨化二醇中位数显著降低挪威青年组为81 nmol/l，挪威青年组为23.5 nmol/l，P < 0.001;挪威孕妇36 nmol/l，P < 0.05），而s-iPTH显著高于挪威孕妇25 nmol/l，P < 0.05（年轻的爱沙尼亚人5.7 pmol/l vs年轻的挪威人2.4 pmol/l，P < 0.001;怀孕的爱沙尼亚人4.8 pmol/l vs怀孕的挪威人2.8 pmol/l，P < 0.02）。尽管有充足的紫外线辐射，但与挪威人相比，来自阿迪斯的人的生化维生素D缺乏率很高。
Objective: To compare Vitamin D status in an African population living at 10 degrees N with a Norwegian population living at 60 degrees N.Design: Serum samples from 30 healthy young Ethiopians and 31 full term pregnant women from Addis Ababa were collected in September, and from 24 healthy Norwegians in March and 23 pregnant women from Oslo in February to June.Methods: Serum (s) levels of calcidiol and intact parathyroid hormone (iPTH) were measured,Results: The median values for s-calcidiol were significantly lower in Ethiopians compared with Norwegians (young Ethiopians 23.5 nmol/l vs young Norwegians 81 nmol/l, P < 0.001; pregnant Ethiopians 25 nmol/l vs pregnant Norwegians 36 nmol/l, P < 0.05) while those for s-iPTH were significantly higher (young Ethiopians 5.7 pmol/l vs young Norwegians 2.4 pmol/l, P < 0.001; pregnant Ethiopians 4.8 pmol/l vs pregnant Norwegians 2.8 pmol/l, P < 0.02).Conclusion: La spite of abundant availability of ultraviolet radiation, the population from Addis Ababa had a high rate of biochemical vitamin D deficiency compared with the Norwegian group.