Dense deposit disease: its possible pathogenesis suggested by an observation of a patient.
Dense deposit disease: its possible pathogenesis suggested by an observation of a patient.
复制标题
致密沉积病：对患者的观察表明其可能的发病机制。
作者：
H. Sato;T. Saito;J. Seino;T. Ootaka;Y. Kyogoku;T. Furuyama;K. Yoshinaga
一名8岁女孩因肾病综合征住院一年。肾活检显示系膜和毛细血管内增生伴分叶。电镜下未见致密存款，但在大多数毛细血管袢中发现致密层分层。她的病情在几个月内通过类固醇治疗得到改善，但中度蛋白尿持续存在。五年半后，随访活检显示致密存款病的典型病理特征。提示第一次活检时致密层的分层可能与第二次活检时肾小球基底膜的致密改变有关。
A girl, aged 8, was admitted to a hospital in a state of nephrotic syndrome of one year's duration. The renal biopsy showed mesangial and endocapillary proliferations with lobulation. Dense deposit was not demonstrated by electron microscopy, but lamellation of the lamina densa was found in most of the capillary loops. Her condition was improved by steroid treatment in a few months, but moderate proteinuria persisted. Five and half years later, follow-up biopsy showed typical pathological features of dense deposit disease. It is suggested that the lamellation of the lamina densa in the first biopsy could be related to the dense alteration of glomerular basement membrane in the second biopsy.