Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study.
Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study.
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精神分裂症患者及其未受影响的父母在 N-Back 工作记忆任务期间大脑低效激活：一项家庭功能磁共振成像研究。
DOI：
10.1371/journal.pone.0135468
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Jiang S;Yan H;Chen Q;Tian L;Lu T;Tan HY;Yan J;Zhang D
研究表明，工作记忆缺陷是精神分裂症症状学的核心特征，可以在患者及其未受影响的亲属中检测到。许多功能磁共振成像（fMRI）研究发现，工作记忆的损害与大脑区域的异常活动有关。本研究调查了精神分裂症患者的大脑区域激活是如何改变的，以及它是如何独立于表现缺陷而遗传的。在N-back任务中，作者使用fMRI方法评估了四组（每组N = 20人，与任务表现、年龄、性别和教育程度相匹配）的工作记忆相关皮层激活情况：精神分裂症患者，其未受影响的亲生父母，患者为年轻健康对照组，父母为老年健康对照组。与健康对照组相比，患者右侧背外侧前额叶皮层（brodmann区[BA] 46）和双侧腹外侧前额叶皮层反应过度，双侧背外侧前额叶皮层（BA 9）激活减少。在联合分析中，遗传风险的影响（父母与老年对照）与疾病的影响（患者与年轻对照）在右侧额叶中回（ba46）和左侧顶叶下回（ba40）有显著重叠的激活。背侧前额叶皮层在工作记忆功能上的生理效率低下和腹侧前额叶皮层的代偿性参与可能是精神分裂症的生理特征之一。背外侧前额叶皮层相对低效的激活可能是精神分裂症的一种有希望的中间表型。
It has been suggested that working memory deficits is a core feature of symptomatology of schizophrenia, which can be detected in patients and their unaffected relatives. The impairment of working memory has been found related to the abnormal activity of human brain regions in many functional magnetic resonance imaging (fMRI) studies. This study investigated how brain region activation was altered in schizophrenia and how it was inherited independently from performance deficits. The authors used fMRI method during N-back task to assess working memory related cortical activation in four groups (N = 20 in each group, matching task performance, age, gender and education): schizophrenic patients, their unaffected biological parents, young healthy controls for the patients and older healthy controls for their parents. Compared to healthy controls, patients showed an exaggerated response in the right dorsolateral prefrontal cortex (brodmann area [BA] 46) and bilateral ventrolateral prefrontal cortex, and had reduced activation in bilateral dorsolateral prefrontal cortex (BA 9). In the conjunction analysis, the effect of genetic risk (parents versus older control) shared significantly overlapped activation with effect of disease (patients versus young control) in the right middle frontal gyrus (BA 46) and left inferior parietal gyrus (BA 40). Physiological inefficiency of dorsal prefrontal cortex and compensation involvement of ventral prefrontal cortex in working memory function may one physiological characteristics of schizophrenia. And relatively inefficient activation in dorsolateral prefrontal cortex probably can be a promising intermediate phenotype for schizophrenia.