Serum and cerebrospinal fluid cytokine profile of patients with 2009 pandemic H1N1 influenza virus-associated encephalopathy
Serum and cerebrospinal fluid cytokine profile of patients with 2009 pandemic H1N1 influenza virus-associated encephalopathy
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DOI：
10.1016/j.cyto.2011.01.006
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发表时间：
2011-05-01
期刊：
影响因子：
3.8
通讯作者：
Ichiyama, Takashi
中科院分区：
文献类型：
--
作者：
Hasegawa, Shunji;Matsushige, Takeshi;Ichiyama, Takashi
目的：自2009年4月以来，与世界其他地区一样，日本感染2009年H1N1流感病毒的患者人数一直在增加。2009年H1N1流感相关脑病（pIE）患者也有报告。这种情况的常见临床症状是癫痫发作和进行性昏迷伴高热。我们先前报道了季节性流感相关脑病（sIE）和促炎细胞因子之间的可能联系。结果：预后不良的PIE患者血清IL-6、IL-10和可溶性肿瘤坏死因子（TNF）受体（sTNFR 1）水平显著高于无神经系统后遗症的PIE患者。同样，预后不良的pIE患者的脑脊液（CSF）IL-6水平显著高于无神经系统后遗症的pIE患者。结论：我们的研究结果表明，IL-6，TNF-α和IL-10在PIE中起重要作用，IL-6，IL-10和sTNFR 1的血清水平和IL-6的CSF水平与神经系统并发症有关。(C)2011爱思唯尔有限公司版权所有。
Purpose: Since April 2009, the number of patients with 2009 pandemic H1N1 influenza virus infection has been increasing in Japan just as in the rest of the world. Patients with 2009 pandemic H1N1 influenza-associated encephalopathy (pIE) have also been reported. The common clinical symptoms of this condition are seizures and progressive coma with high-grade fever. We previously reported the possible association between seasonal influenza-associated encephalopathy (sIE) and proinflammatory cytokines. However, the pathogenesis of pIE remains to be elucidated.Results: In PIE patients with a poor outcome, the serum levels of interleukin (IL)-6, IL-10, and soluble tumor necrosis factor (TNF) receptor (sTNFR1) were significantly higher than those in pIE patients without neurological sequelae. Similarly, the cerebrospinal fluid (CSF) IL-6 levels in pIE patients with a poor outcome were significantly higher than those in pIE patients without neurological sequelae. Conclusion: Our results suggest that IL-6, TNF-alpha, and IL-10 play important roles in PIE, and that the serum levels of IL-6, IL-10, and sTNFR1 and the CSF levels of IL-6 are related to neurological complications. (C) 2011 Elsevier Ltd All rights reserved.