Positional cloning of the mouse obese gene and its human homologue
Positional cloning of the mouse obese gene and its human homologue
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DOI：
10.1038/374479a0
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发表时间：
1995
期刊：
影响因子：
64.8
通讯作者：
Yiying Zhang;R. Proenca;M. Maffei;M. Barone;L. Leopold;J. Friedman
中科院分区：
文献类型：
--
作者：
Yiying Zhang;R. Proenca;M. Maffei;M. Barone;L. Leopold;J. Friedman
平衡食物摄入和能量消耗的机制决定了谁会肥胖，谁会瘦。肥胖基因是调节老鼠体内能量平衡的分子之一。obb基因突变导致严重肥胖和II型糖尿病，这是一种类似人类病态肥胖的综合征的一部分。Theobgene产物可以作为脂肪组织的信号通路的一部分起作用，该信号通路用于调节身体脂肪库的大小。
The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is theobese(ob) gene. Mutation ofobresults in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. Theobgene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.