Low-dose X-ray-stimulated LaGaO3:Sb,Cr near-infrared persistent luminescence nanoparticles for deep-tissue and renewable in vivo bioimaging
Low-dose X-ray-stimulated LaGaO3:Sb,Cr near-infrared persistent luminescence nanoparticles for deep-tissue and renewable in vivo bioimaging
复制标题
低剂量 X 射线刺激 LaGaO3:Sb,Cr 近红外持久发光纳米颗粒，用于深层组织和可再生体内生物成像
DOI：
10.1016/j.cej.2020.127133
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发表时间：
2021-01-15
影响因子：
15.1
通讯作者：
Wang, Jing
中科院分区：
文献类型：
--
作者：
Liu, Bo-Mei;Zou, Rui;Wang, Jing
X射线激发的近红外持久发光纳米粒子(NIR-PLNPs)具有诱人的无自体荧光深部成像和深度无关治疗能力，但仍受到高剂量X射线照射(>；5Gy)的不利影响。本文从X射线光子吸收中心和缺陷中心两个中心的角度出发，提出了一种自上而下的成分设计策略，用于开发具有更高的X射线光子吸收效率和优化的持久发光(Persl)性能的低剂量X射线刺激的NIR-PLNPs。成功地制备了超灵敏的X射线激发近红外PLNPs材料LaGaO_3：Sb~(3+)，Cr3+，在750 nm附近具有超长的Persl发射(>；500h)。主体LaGaO_3的高Z原子组分的性质赋予了这些NIR-PLNPs很强的X射线吸收能力。通过与尺寸不匹配的离子Sb3+共掺杂，合理地优化了基质中的氧空位浓度，从而提高了Cr3+离子的近红外光谱性能。体内生物成像表明，所设计的X射线刺激的近红外PLNPs LaGaO_3：Sb~(3+)，Cr3+在X射线照射下可以很容易地被激活，甚至在0.37GyX射线照射下也能被激活，显示了这些纳米粒子在深层次成像和治疗方面的优势。更重要的是，我们预计我们提出的自上而下的成分设计策略可以在未来开发出更低剂量的X射线刺激的近红外-PLNPs。
X-ray-stimulated near-infrared persistent luminescence nanoparticles (NIR-PLNPs) offer attractive capabilities for autofluorescence free deep-seated imaging and depth-independent treatment, but still suffer from adverse effects caused by high-dose X-ray irradiation (>5 Gy). From the viewpoint of two centers of NIR-PLNPs, i.e., X-ray photon absorption center and defects center, we here propose a top-down composition design strategy for the development of low dose X-ray-stimulated NIR-PLNPs with improved X-ray photon absorption efficiency and optimized persistent luminescence (PersL) performance. Successfully, hypersensitive X-ray-stimulated NIR-PLNPs LaGaO3:Sb3+,Cr3+ with a super-long PersL emission (>500 h) at similar to 750 nm are prepared. The nature of high Z atomic constituents of the host LaGaO3 endows these NIR-PLNPs with strong X-ray absorption capacity. Simply by codoping with size-mismatched ions Sb3+, the concentration of oxygen vacancies in the host is rationally optimized, leading to the enhanced NIR PersL performance of Cr3+ ions. In vivo bioimaging demonstrates that the designed X-ray-stimulated NIR-PLNPs LaGaO3:Sb3+,Cr3+ can be readily reactivated under X-ray irradiation with even a lower dose to 0.37 Gy, showing the advantages of these nanoparticles on deep-seated imaging and treatment. More importantly, we anticipate that our proposed top-down composition design strategy can be applied to develop much low dose X-ray-stimulated NIR-PLNPs in the future.