Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III.
Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III.
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在没有抗凝血酶 III 的情况下，肝素组分可抑制凝血酶催化的凝血反应和血小板活化反应。
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
C. Hemker
中科院分区：
文献类型：
--
作者：
Dominique Baruch;T. Lindhout;R. Wagenvoord;C. Hemker
The antithrombin-III-independent effect of heparin was studied in the following thrombin-catalyzed reactions: activation of purified plasma factor V and partially purified plasma factor VIII:C, generation of factor Va from the platelets and, in the presence of collagen, of the platelet procoagulant activity. Five heparin fractions and a heparinoid were compared to crude heparin. Crude heparin was a more potent inhibitor of these reactions than the fractions or the heparinoid. The inhibitory action of heparin (fractions) appeared to be the result of the formation of a complex between heparin and thrombin that alters the specificity of thrombin towards high molecular weight substrates. The inhibition of these thrombin-dependent feedback reactions in blood coagulation might be of importance in the mechanisms for the dissociation between the antithrombotic and hemorrhagic properties of low molecular weight heparins.
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DOI：
10.1172/jci111028
发表时间：
1983-09
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
R. Hurst;M. Poon;M. Griffith
通讯作者：
R. Hurst;M. Poon;M. Griffith
肝素增强的抗凝血酶 III/凝血酶反应对于凝血酶和抗凝血酶 III 都是可饱和的。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Griffith,MJ
通讯作者：
Griffith,MJ
描述抗凝血酶 III 和凝血酶之间肝素催化反应动力学的简单速率定律。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Nesheim,ME
通讯作者：
Nesheim,ME
体外循环患者异常出血的机制：与选择性α颗粒释放相关的获得性短暂血小板功能障碍。
影响因子：
20.3
作者：
Harker,LA;Malpass,TW;Branson,HE;Hessel2nd,EA;Slichter,SJ
通讯作者：
Slichter,SJ