Impact of acute hepatitis B virus superinfection on chronic hepatitis C virus infection
Impact of acute hepatitis B virus superinfection on chronic hepatitis C virus infection
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DOI：
10.1111/j.1572-0241.2000.02337.x
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发表时间：
2000-10-01
影响因子：
9.8
通讯作者：
Tsai, SL
中科院分区：
文献类型：
--
作者：
Liaw, YF;Yeh, CT;Tsai, SL
B型肝炎病毒（HBV）和丙型肝炎病毒（HCV）双重感染并不少见，但急性HBV重叠感染对慢性HCV感染患者的影响仍不清楚。2例慢性HCV感染患者因急性肝炎住院，血清学证实为急性HBV重叠感染。1例入院时血清HBV-DNA和HCV-RNA均阳性的患者死于肝功能衰竭。另1例HCV-RNA血清学阴性，丙氨酸氨基转移酶正常化，HBsAg血清学清除，HCV抗体恢复。这些发现证实了慢性肝炎患者的急性重叠感染可能会增加重型肝炎的风险，并表明HBV作为新的病毒可能会抑制预先存在的HCV。与早期观察到的急性HCV重叠感染抑制了既存HBV一起，似乎感染的时间或顺序是影响病毒相互作用结果的一个因素。(Am胃肠病学杂志2000;95：2978-2980. (C)2000年，我胃肠病学）。
Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection is not uncommon, but the impact of acute HBV superinfection in patients with chronic HCV infection is still unknown. Two patients with well documented chronic HCV infection were hospitalized for acute hepatitis, which was serologically confirmed to be acute HBV superinfection. One patient who was seropositive for both HBV-DNA and HCV-RNA upon admission died of hepatic failure. The other became seronegative for HCV-RNA and recovered with alanine aminotransferase normalization, seroclearance of HBsAg, and antibodies to HCV. These findings confirm that acute superinfection in patients with chronic hepatitis may increase the risk for severe hepatitis, and suggest that HBV as the newcomer may suppress the pre-existing HCV. Together with the earlier observation that acute HCV superinfection suppresses pre-existing HBV, it seems that the timing or sequence of infection is a factor influencing the outcome of viral interactions. (Am J Gastroenterol 2000;95: 2978-2980. (C) 2000 by Am. Coll. of Gastroenterology).