Wound Healing and Skin Regeneration
Wound Healing and Skin Regeneration
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DOI：
10.1101/cshperspect.a023267
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发表时间：
2015-01-01
影响因子：
5.4
通讯作者：
Ito, Mayumi
中科院分区：
文献类型：
--
作者：
Takeo, Makoto;Lee, Wendy;Ito, Mayumi
皮肤是一个复杂的器官，包括表皮、真皮层和皮肤附属物，包括毛囊和皮脂腺。成年哺乳动物的伤口愈合会导致没有任何皮肤附属物的疤痕形成。研究报告了胎儿皮肤无疤痕愈合和成人皮肤附属物再生的显著例子。这些研究中使用的模型为研究哺乳动物伤口愈合和皮肤再生的细胞和分子机制提供了一个新的平台。在这篇文章中，我们将关注皮肤附属物对伤口愈合的贡献，以及相反的，损伤后皮肤附属物的再生。
The skin is a complex organ consisting of the epidermis, dermis, and skin appendages, including the hair follicle and sebaceous gland. Wound healing in adult mammals results in scar formation without any skin appendages. Studies have reported remarkable examples of scarless healing in fetal skin and appendage regeneration in adult skin following the infliction of large wounds. The models used in these studies have offered a new platform for investigations of the cellular and molecular mechanisms underlying wound healing and skin regeneration in mammals. In this article, we will focus on the contribution of skin appendages to wound healing and, conversely, skin appendage regeneration following injuries.