Glyconanomaterials: Emerging applications in biomedical research.
Glyconanomaterials: Emerging applications in biomedical research.
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DOI：
10.1007/s12274-014-0507-y
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发表时间：
2014-10
期刊：
影响因子：
9.9
通讯作者：
Yan M
中科院分区：
文献类型：
--
作者：
Chen X;Ramström O;Yan M
碳水化合物是自然界中最丰富的有机物质，作为结构成分和能源，调节着广泛的细胞活动。具有独特的光学、磁学和电学性质的纳米材料的出现见证了这些材料在生物医学研究和应用中的迅速采用。具有大比表面积的各种形状和尺寸的纳米材料可以作为多价支架来呈现碳水化合物配体。由此产生的糖异构体有效地放大了糖介导的相互作用，使得将这些材料用于传感、成像、诊断和治疗成为可能。在这篇综述中，我们总结了各种糖金属材料的合成策略。给出了这些糖异构体用于蛋白质和细胞的传感和分化，以及用于成像糖类药物细胞反应的例子。
Carbohydrates constitute the most abundant organic matter in nature, serving as structural components and energy sources, and mediating a wide range of cellular activities. The emergence of nanomaterials with distinct optical, magnetic, and electronic properties has witnessed a rapid adoption of these materials for biomedical research and applications. Nanomaterials of various shapes and sizes having large specific surface areas can be used as multivalent scaffolds to present carbohydrate ligands. The resulting glyconanomaterials effectively amplify the glycan-mediated interactions, making it possible to use these materials for sensing, imaging, diagnosis, and therapy. In this review, we summarize the synthetic strategies for the preparation of various glyconanomaterials. Examples are given where these glyconanomaterials have been used in sensing and differentiation of proteins and cells, as well as in imaging glycan-medicated cellular responses.